TolbutamideA hypoglycemic agonist for secretion of islet hormones

Tolbutamide (CAS 64-77-7)

Tolbutamide | CAS 64-77-7 is rated 5.0 out of 5 by 1.
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Synonym: 1-Butyl-3-(4-methylphenylsulfonyl)urea
Application: A hypoglycemic agonist for secretion of islet hormones
CAS Number: 64-77-7
Purity: ≥98%
Molecular Weight: 270.35
Molecular Formula: C12H18N2O3S
* Refer to Certificate of Analysis for lot specific data (including water content).
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Tolbutamide is a sulfonylurea agonist for secretion of insulin by beta-cells. In rat pancreatic β-cells cultured in the presence of Tolbutamide displayed increased numbers of beta-cells in a dose responsive manner with beta-cell numbers doubling at 100 μg/ml of Tolbutamide. The compound displayed inhibitory action towards beta-cells at concentrations greater than 100 μg/ml. In addition in the presence of low glucose concentrations Tolbutamide's cytotrophic action was inhibited. On isolated dog pancreas islets Tolbutamide at 180 μM stimulated the release of somatostatin, insulin and glucagon in the absence of glucose. in all situations the loss of Ca2+ eliminated all effects of Tolbutamide. The compound has been observed to mechanistically enhance the secretion of insulin by highly selective amplification of insulin secretory burst mass.


References

1. Hermansen, K. 1982. Acta Endocrinol. 99: 86-93. PMID: 6120607
2. Popiela, H. and Moore, W. 1991. Pancreas. 6: 464-469. PMID: 1876602
3. Pørksen, N.K., et al. 1996. Diabetes. 45: 1792-1797. PMID: 8922367

Physical State :
Solid
Solubility :
Soluble in DMSO or 100% ethanol; insoluble in water.
Storage :
Store at room temperature
Boiling Point :
~430° C (Predicted)
Density :
~1.18 g/cm3 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
5505
MDL Number :
MFCD00027169
EC Number :
200-594-3
SMILES :
CCCCNC(=O)NS(=O)(=O)C1=CC=C(C=C1)C

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Tolbutamide  Product Citations

See how others have used Tolbutamide. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 27826078  Landa-Juárez, AY. et al. 2016. Eur. J. Pharmacol. 793: 95-100.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Henquin Henquin, JC. et al. (PubMed 24977470) used Tolbutamide and glucose to stimulate female mouse islets. -SCBT Publication Review
Date published: 2015-01-12
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