TNP-ATP triethylammonium saltA P2X receptor antagonist

TNP-ATP triethylammonium salt (CAS 61368-63-6)

TNP-ATP triethylammonium salt | CAS 61368-63-6 is rated 5.0 out of 5 by 1.
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Synonym: 2',3'-O-(2,4,6-Trinitrophenyl)adenosine-5'-triphosphate tetra(triethylammonium) salt
Application: A P2X receptor antagonist
CAS Number: 61368-63-6
Purity: ≥95%
Molecular Weight: 1123.04
Molecular Formula: C16H13N8O19P3•C24H64N4
* Refer to Certificate of Analysis for lot specific data (including water content).
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TNP-ATP triethylammonium salt is a selective P2X receptor antagonist which inhibits ATP-induced currents in cells, specifically P2X1, P2X3 and heteromeric P2X2/3 receptors. In addition, studies show that TNP-ATP triethylammonium salt is 1000 times more selective towards P2X2 receptors than P2X4 and P2X7. Alternate studies indicate that TNP-ATP triethylammonium salt is more potent than TNP-AMP at reducing acetic acid-induced nociception in mice. Furthermore, TNP-ATP triethylammonium salt competes with &alpha,&beta-meATP to bind to the P2X receptors once both ligands reach a steady state condition. Also TNP-ATP triethylammonium salt can be used as a probe to detect the nucleotide binding site of CheA which upon binding results in an inhibition of autophosphorylation.


References

1. Stewart, R.C., et al. 1998. Biochemistry. 37: 12269-12279. PMID: 9724541
2. Burgard, E.C., et al. 2000. Mol. Pharmacol. 58: 1502-1510. PMID: 11093790
3. Honore, P., et al. 2002. Pain. 96: 99-105. PMID: 11932066

Formulation :
10 mM in water
Physical State :
Liquid
Solubility :
Soluble in water at 10 mM (supplied pre-dissolved at a concentration of 10mM).
Storage :
Desiccate at -20° C
Refractive Index :
n20D 1.95 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
AU7460200
MDL Number :
MFCD08669665
SMILES :
CC[NH+](CC)CC.CC[NH+](CC)CC.CC[NH+](CC)CC.CC[NH+](CC)CC.Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(=O)([O-])OP(=O)([O-])OP(=O)([O-])O)[C@H]2OC3(O[C@@H]12)C(=CC(=[N+]([O-])[O-])C=C3[N+](=O)[O-])[N+](=O)[O-]

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Certificate of Analysis

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TNP-ATP triethylammonium salt  Product Citations

See how others have used TNP-ATP triethylammonium salt. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 23946885  Chiraniya, A. et al. 2013. Genes (Basel). 4: 134-51.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Honore Honore, P. et al. (PubMed 11932066) reported that TNP-ATP, a potent P2X3 receptor antagonist, blocks acetic acid-induced abdominal constriction in mice. -SCBT Publication Review
Date published: 2015-03-13
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