TNP-ATP triethylammonium salt is a selective P2X receptor antagonist which inhibits ATP-induced currents in cells, specifically P2X1, P2X3 and heteromeric P2X2/3 receptors. In addition, studies show that TNP-ATP triethylammonium salt is 1000 times more selective towards P2X2 receptors than P2X4 and P2X7. Alternate studies indicate that TNP-ATP triethylammonium salt is more potent than TNP-AMP at reducing acetic acid-induced nociception in mice. Furthermore, TNP-ATP triethylammonium salt competes with &alpha,&beta-meATP to bind to the P2X receptors once both ligands reach a steady state condition. Also TNP-ATP triethylammonium salt can be used as a probe to detect the nucleotide binding site of CheA which upon binding results in an inhibition of autophosphorylation.
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HonoreHonore, P. et al. (PubMed 11932066) reported that TNP-ATP, a potent P2X3 receptor antagonist, blocks acetic acid-induced abdominal constriction in mice. -SCBT Publication Review
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