TNF-alpha InhibitorA selective inhibitor of TNF-α

TNF-α Inhibitor (CAS 1049741-03-8)

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Synonym: 6,7-Dimethyl-3-((methyl-(2-(methyl-(1-(3-trifluoromethyl-phenyl)-1H-indol-3-ylmethyl)-amino)-ethyl)-amino)-methyl)-chromen-4-one, diHCl
Application: A selective inhibitor of TNF-α
CAS Number: 1049741-03-8
Purity: ≥95%
Molecular Weight: 629.6
Molecular Formula: C32H32F3N3O22HCl•1/2H2O
* Refer to Certificate of Analysis for lot specific data (including water content).

TNF-α Inhibitor is a cell-permeable indolyl-chromenone compound reported to rapidly inactivate TNF-α via non-covalently binding to the TNF-α trimer, promoting subunit dissociation and preventing TNF-α binding to its receptor. Additionally reported to selectively inhibit TNF-α-, but not IL-1β-induced Iκβ-α degradation in HeLa cells.


References

1. He, M.M., et al. 2005. Science. 310: 1022-1025. PMID: 16284179

Physical State :
Solid
Solubility :
Soluble in DMSO (10 mg/ml).
Storage :
Store at -20° C
Refractive Index :
n20D ~1.58 (Predicted)
IC50 :
TNFR1 receptor binding to TNF-a: IC50 = 22 µM; TNF-a-mediated stimulation of IkB degradation: IC50 = 4.6 µM (HeLa cells )
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
16079006
SMILES :
CC1=C(C=C2C(=C1)C(=O)C(=CO2)CN(C)CCN(C)CC3=CN(C4=CC=CC=C43)C5=CC=CC(=C5)C(F)(F)F)C.Cl.Cl

Download SDS (MSDS)

Certificate of Analysis

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What is the stability of this compound (TNF-alpha inhibitor) in solution and at incubator temperature?

Asked by: LeeF
Thank you for your question. We recommend after reconstitution to aliquot and freeze; solutions are stable for up to 3 months if stored at -20C.
Answered by: Technical Support
Date published: 2019-01-26
  • y_2019, m_9, d_16, h_23CST
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