TNF-alpha AntagonistA cyclic peptide that mimics the most critical TNF recognition loop on TNF-R1

TNF-α Antagonist (CAS 199999-60-5)

TNF-α Antagonist, CAS 199999-60-5 is rated 5.0 out of 5 by 1.
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Synonym: H-Tyr-Cys-Trp-Ser-Gln-Tyr-Leu-Cys-Tyr-OH
Application: A cyclic peptide that mimics the most critical TNF recognition loop on TNF-R1
CAS Number: 199999-60-5
Molecular Weight: 1226.40
Molecular Formula: C58H71N11O15S2
* Refer to Certificate of Analysis for lot specific data (including water content).
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TNF-α Antagonist, also designated WP9QY is an exocyclic peptidomimetic that acts as a TNF-α antagonist by mimicking the most critical recognition loop on TNF receptor I, thus preventing interaction with the receptor. By blocking the TNFR ligand contact site, the peptide blocks bone resorption by interfering with recruitment and activation of osteoclasts by both RANKL and TNF. Useful for the development of small molecular inhibitors related to the prevention of systemic bone loss in rheumatoid arthritis and inflammatory bone destruction. The designation WP9QY arises from the binding to the site observed in the TNF receptor complex.


References

1. Takasaki, W., et al. 1997. Nat. Biotechnol. 15: 1266-1270. PMID: 9359109
2. Mimori, K., et al. 2003. Leukemia. 17: 1164-1174. PMID: 12764385
3. De Biase, L., et al. 2003. Thromb. Haemost. 90: 317-325. PMID: 12888880
4. Kojima, T., et al. 2005. J. Med. Dent. Sci. 52: 91-99. PMID: 15868746
5. Aoki, K., et al. 2006. J. Clin. Invest. 116: 1525-1534. PMID: 16680194
6. Suzuki, Y., et al. 2006. J. Periodont. Res. 41: 81-91. PMID: 16499710
7. Saito, H., et al. 2007. Arthritis Rheum. 56: 1164-1174. PMID: 17393436
8. Doherty, G.H. 2007. Neurosci. Res. 57: 296-305. PMID: 17150272

Physical State :
Solid
Sequence :
YCWSQYLCY (Disulfide bridge: 2-8)
Solubility :
Soluble in 5% acetic acid (5 mg/ml), and cold water (1 mg/ml).
Storage :
Store at -20° C
IC50 :
TNF-α: IC50 = 5 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

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TNF-alpha Antagonist  Product Citations

See how others have used TNF-alpha Antagonist. Click on the entry to view the PubMed entry .

Citations 1 to 5 of 5 total

PMID: # 27746371  Kim, HR. et al. 2017. Toxicol In Vitro. 38: 1-7.

PMID: # 27226618  Han, C. et al. 2016. The Journal of biological chemistry.

PMID: # 26373796  Zhou, B.|Li, H.|Liu, J.|Xu, L.|Guo, Q.|Sun, H.|Wu, S.| et al. 2015. J. Mol. Endocrinol. 55: 231-43.

PMID: # 25400729  Wang, JH. et al. 2014. International journal of clinical and experimental pathology. 7: 6514-23.

PMID: # 24405660  Huang, CY. et al. 2014. Journal of neuroinflammation. 11: 7.

Citations 1 to 5 of 5 total
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Rated 5 out of 5 by from TNF TNF- Antagonist is a peptide that has been reported to imitate the TNF-alpha recognition loop on TNF receptor I complex. This imitation causes interferences with both TNF-alpha's recruitment and activation of osteoclasts and activating receptor activator of NF-kappaB (RANK). In many studies, TNF-alpha antagonist is also known to block bone resorption in rheumatoid arthritis. -SCBT Publication Review
Date published: 2015-04-05
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