TN-16An antitumor drug that blocks microtubule assembly

TN-16 (CAS 33016-12-5)

TN-16 | CAS 33016-12-5 is rated 5.0 out of 5 by 1.
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Application: An antitumor drug that blocks microtubule assembly
CAS Number: 33016-12-5
Purity: ≥97%
Molecular Weight: 306.36
Molecular Formula: C19H18N2O2
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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TN-16 is a synthetic antitumor drug that blocks microtubule assembly by binding to the colchicine site of Tubulin. TN-16 prevents stabilization of microtubules in Paclitaxel-treated cells. The compound also blocks the cell cycle in M phase.


References

Yamaguchi, Y., et al. 1995. Cell Struct. Funct. 20, 47. Gupta, R.S. 1986. Mol. Pharmacol. 30, 142. Roach, M.C. and Luduena, R.F. 1985. Biochem. Biophys. Res. Commun. 129, 200. Arai, T. 1983. FEBS Lett.155, 273.

Physical State :
Solid
Solubility :
Soluble in DMSO (25 mg/ml), warm ethanol (12.5 mg/ml), and DMF.
Storage :
Store at room temperature
Melting Point :
182-185° C
Boiling Point :
532.69° C at 760 mmHg (Predicted)
Density :
1.25 g/cm3 (Predicted)
Refractive Index :
n20D 1.65 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
6088175
MDL Number :
MFCD02684017
SMILES :
C/C(=C\\1/C(=O)C(NC1=O)CC2=CC=CC=C2)/NC3=CC=CC=C3

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Certificate of Analysis

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What is the solubility in DMF?

Asked by: chemicalsmg
Thank you for your question. TN-16: sc-204347 is soluble in DMF at 12.5 mg/ml.
Answered by: Chemical Support 3
Date published: 2017-04-07
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Rated 5 out of 5 by from Arai Arai, T. et al. (PubMed 6852237) reported that TN-16 inhibited microtubule assembly in vitro. -SCBT Publication Review
Date published: 2015-07-15
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