TMS CAS: 24144-92-1
MF: C18H20O4
MW: 300.35
An inhibitor of cytochrome P450 1B1 and cancer cell growth.

TMS (CAS 24144-92-1)

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Alternate Names: 2,3',4,5'-Tetramethoxystilbene; 1-[(1E)-2-(3,5-dimethoxyphenyl)ethenyl]-2,4-dimethoxy-benzene
Application: TMS is an inhibitor of cytochrome P450 1B1 and cancer cell growth
CAS Number: 24144-92-1
Purity: ≥98%
Molecular Weight: 300.35
Molecular Formula: C18H20O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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TMS is a strong, selective and competitive inhibitor of cytochrome P450 1B1, an overexpressed enzyme in particular tumors (IC50 = 6 nM). 50- and 520-fold selective over P450 1A1 and 1A2 respectively. TMS inhibits cancer cell growth in vitro.


References

1. Nam, K.A., et al. 2001. Arch. Pharm. Res. 24: 441-445.
2. Chun, Y.J., et al. 2001. Cancer Res. 61: 8164-8170.
3. Kim, S., et al. 2002. J. Med. Chem. 45: 160-164.

Physical State :
Solid
Solubility :
Soluble in ethanol (25 mM), DMSO (100 mM), water (0.5 mg/ml at 25° C), DMF (~20 mg/ml), and methanol.
Storage :
Store at -20° C
Melting Point :
137.99° C (Predicted)
Boiling Point :
~459.9° C at 760 mmHg (Predicted)
Density :
~1.1 g/cm3 (Predicted)
Refractive Index :
n20D 1.59 (Predicted)
IC50 :
Cell growth : IC50 = 0.8 nM (human lung carcinoma cells ); CYP1B1: IC50 = 6 nM (human); CYP1A1: IC50 = 300 nM (human); CYP1A2: IC50 = 3.1 µM (human); ADMET: IC50 = 5.6 µM
Ki Data :
CYP1B1: Ki= 3 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :
MFCD03428621
SMILES :
COC1=CC(=C(C=C1)/C=C/C2=CC(=CC(=C2)OC)OC)OC

Download SDS (MSDS)

Certificate of Analysis

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