TMPyP4, tetra-(N-methyl-4-pyridyl)porphyrin, is a potent inhibitor of human TERT (telomerase, IC50 = 6.5 μM). TMPyP4 binds strongly to DNA quadruplexes by stacking on the G-tetrads at the core of the quadruplex, resulting in telomerase inhibition. TMPyP4 fluoresces intensely in the presence of quadruplex DNA.
1. Anantha, N.V., et al. 1998. Biochemistry. 37: 2709-2714. PMID: 9537740 2. Izbicka, E., et al. 1999. Cancer Res. 59: 639-644. PMID: 9973212 3. Shi, D.F., et al. 2001. J. Med. Chem. 44: 4509-4523. PMID: 11741471 4. Yamashita, T., et al. 2005. Bioorg. Med. Chem. 13: 2423-2430. PMID: 15755644
Soluble in water (1 mg/ml).
Store at 4° C
telomerase: IC50 = 6.5 µM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Rated 5 out of
Zhang et alZhang et al. (PubMed ID 26382555) found that TMPyP4 inhibited proliferation and induced apoptosis in SW480 cells via the suppression of the Wnt/ -catenin signaling pathway. -SCBT Publication Review
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