TMPyP4A potent inhibitor of telomerase activity

TMPyP4 (CAS 36951-72-1)

TMPyP4 | CAS 36951-72-1 is rated 5.0 out of 5 by 1.
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Synonym: meso-Tetra (N-methyl-4-pyridyl) porphine tetra tosylate
Application: A potent inhibitor of telomerase activity
CAS Number: 36951-72-1
Purity: ≥90%
Molecular Weight: 1363.60
Molecular Formula: C44H38N8•C28H28O12S4
* Refer to Certificate of Analysis for lot specific data (including water content).
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TMPyP4, tetra-(N-methyl-4-pyridyl)porphyrin, is a potent inhibitor of human TERT (telomerase, IC50 = 6.5 μM). TMPyP4 binds strongly to DNA quadruplexes by stacking on the G-tetrads at the core of the quadruplex, resulting in telomerase inhibition. TMPyP4 fluoresces intensely in the presence of quadruplex DNA.


References

1. Anantha, N.V., et al. 1998. Biochemistry. 37: 2709-2714. PMID: 9537740
2. Izbicka, E., et al. 1999. Cancer Res. 59: 639-644. PMID: 9973212
3. Shi, D.F., et al. 2001. J. Med. Chem. 44: 4509-4523. PMID: 11741471
4. Yamashita, T., et al. 2005. Bioorg. Med. Chem. 13: 2423-2430. PMID: 15755644

Physical State :
Solid
Solubility :
Soluble in water (1 mg/ml).
Storage :
Store at 4° C
IC50 :
telomerase: IC50 = 6.5 µM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
11979833
MDL Number :
MFCD00013468
Beilstein Registry :
6049195
SMILES :
CC1=CC=C(C=C1)S(=O)(=O)[O-].CC1=CC=C(C=C1)S(=O)(=O)[O-].CC1=CC=C(C=C1)S(=O)(=O)[O-].CC1=CC=C(C=C1)S(=O)(=O)[O-].C[N+]1=CC=C(C=C1)C2=C3C=CC(=C(C4=CC=C(N4)C(=C5C=CC(=N5)C(=C6C=CC2=N6)C7=CC=[N+](C=C7)C)C8=CC=[N+](C=C8)C)C9=CC=[N+](C=C9)C)N3

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Certificate of Analysis

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HI, I had already ordered you product TMPYP4 SC-204346. now i want its with Zn metal. do you have this product. if yes, what is its SC number

Asked by: jahangoshayi
Thanks for your question. Please contact technical service for support.
Answered by: SCBT Heidelberg Support
Date published: 2019-01-06
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Rated 5 out of 5 by from Zhang et al Zhang et al. (PubMed ID 26382555) found that TMPyP4 inhibited proliferation and induced apoptosis in SW480 cells via the suppression of the Wnt/ -catenin signaling pathway. -SCBT Publication Review
Date published: 2015-01-05
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