Anti-TLR4 Antibody (25) is a mouse monoclonal IgG1 κ TLR4 antibody, cited in 362 publications, provided at 200 µg/ml
raised against amino acids 198-395 of TLR4 of mouse origin
recommended for detection of TLR4 of mouse, rat, human and canine origin by WB, IP, IF and IHC(P)
available conjugated to agarose for IP; and to HRP for WB, IHC(P) and ELISA
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of TLR4 (25): sc-293072.
m-IgG Fc BP-HRP is the preferred secondary detection reagent for TLR4 Antibody (25) for WB and IHC(P) applications. This reagent is now offered in a bundle with TLR4 Antibody (25) (see ordering information below).
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
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Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
TLR4 Antibody (25) is a high quality monoclonal TLR4 antibody (also designated CD284 antibody or toll like receptor 4 antibody) suitable for the detection of the TLR4 protein of mouse, rat, human and canine origin. TLR4 Antibody (25) is available as both the non-conjugated anti-TLR4 antibody form, as well as multiple conjugated forms of anti-TLR4 antibody, including agarose, HRP. Six human homologs of the Drosophila Toll receptor were initially identified based on their sequence similarities and designated toll-like receptors (TLR). Toll receptors are involved in mediating dorsoventral polarization in the developing Drosophila embryo and also participate in the host immunity. The TLR family of proteins are characterized by a highly conserved Toll homology (TH) domain, which is essential for Toll-induced signal transduction. TLR1, as well as the other TLR family members, are type I transmembrane receptors that characteristically contain an extracellular domain consisting of several leucine-rich regions along with a single cytoplasmic Toll/IL-1R-like domain. TLR2 and TLR4 are activated in response to lipopolysacchride (LPS) stimulation, which results in the activation and translocation of NFkB and suggests that these receptors are involved in mediating inflammatory responses. When used in immunostaining applications, TLR4 Antibody (25) displays both nuclear and cytoplasmic staining. Expression of TLR receptors is highest in peripheral blood leukocytes, macrophages, and monocytes. TLR6 is highly homologous to TLR1, sharing greater than 65% sequence identity, and, like other members of TLR family, it induces NFkB signaling upon activation.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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