Tiotropium Bromide is a muscarinic acetylcholine receptor (mAChR M) antagonist that blocks the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel. This stops signaling between neurons and leads to muscle relaxation.
Haddad, E.-B., et al.: Mol. Pharmacol., 45, 899 (1994), Donohue, J. F., et al.: Chest, 122, 47 (2002), Profita, M., et al.: Allergy, 60, 1361 (2005), Dusser, D., et al.: Eur. Respir. J., 27, 547 (2006),
Soluble in DMSO and Methanol
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Anderson et alAnderson et al. (PubMed ID 26301488) found that patients given a beta-agonist treatment in conjunction with the long-acting muscarinic antagonist, tiotropium bromide, had a reduced likelihood of exacerbations requiring treatment and had improved lung function. -SCBT Publication Review
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