Tie2 Kinase Inhibitor

Tie2 Kinase Inhibitor (CAS 948557-43-5)

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Synonym: 4-(6-Methoxy-2-naphthyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole
Application: A cell-permeable inhibitor of Tie2
CAS Number: 948557-43-5
Purity: ≥97%
Molecular Weight: 439.5
Molecular Formula: C26H21N3O2S
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Tie2 Kinase Inhibitor is a cell-permeable pyridinylimidazole which has been reported to act as a potent, reversible, and ATP-binding site-targeting inhibitor of Tie-2(Tie2 )with a reported ~ 200-fold selectivity over p38 MAPK and greater than 10-fold selectivity over Flk-1(VEGFR2), Flt-4 (VEGFR3), and PDGFR-β (PDGFR1β). Additionally, Tie2 Kinase Inhibitor is reported to demonstrate antiangiogenesis activity in a Matrigel assay.


References

1. Semones, M., et al. 2007. Bioorg. Med. Chem. Lett. 17: 4756-4760. PMID: 17618114

Usage :
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Physical State :
Solid
Solubility :
Soluble in DMSO (10 mg/ml), water (< 1 mg/ml), and ethanol (< 1 mg/ml).
Storage :
Store at 4° C
Boiling Point :
699.76° C at 760 mmHg (Predicted)
Density :
1.40 g/cm3 (Predicted)
Refractive Index :
n20D 1.75 (Predicted)
IC50 :
moderate cellular activities: IC50 = 232 nM (HEL cells); Tie2: IC50 = 250 nM; p38: IC50 = 50 µM
pK Values :
pKb: 9.13 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Transport :
UN 3077, Class 9, Packing group III
PubChem CID :
23625762
MDL Number :
MFCD18384977
SMILES :
COC1=CC2=C(C=C1)C=C(C=C2)C3=C(NC(=N3)C4=CC=C(C=C4)S(=O)C)C5=CC=NC=C5

Download SDS (MSDS)

Certificate of Analysis

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