Tie2 Kinase Inhibitor is a cell-permeable pyridinylimidazole which has been reported to act as a potent, reversible, and ATP-binding site-targeting inhibitor of Tie-2(Tie2 )with a reported ~ 200-fold selectivity over p38 MAPK and greater than 10-fold selectivity over Flk-1(VEGFR2), Flt-4 (VEGFR3), and PDGFR-β (PDGFR1β). Additionally, Tie2 Kinase Inhibitor is reported to demonstrate antiangiogenesis activity in a Matrigel assay.
1. Semones, M., et al. 2007. Bioorg. Med. Chem. Lett. 17: 4756-4760. PMID: 17618114
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Soluble in DMSO (10 mg/ml), water (< 1 mg/ml), and ethanol (< 1 mg/ml).
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