Ticrynafen CAS: 40180-04-9
MF: C13H8Cl2O4S
MW: 331.17
A cytochrome P450 inhibitor.

Ticrynafen (CAS 40180-04-9)

Ticrynafen | CAS 40180-04-9 is rated 5.0 out of 5 by 1.
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Application: Ticrynafen is a cytochrome P450 inhibitor
CAS Number: 40180-04-9
Purity: >99%
Molecular Weight: 331.17
Molecular Formula: C13H8Cl2O4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ticrynafen is a heterocyclic derivative of phenoxyacetic acid which inhibits cytochrome P450 (CYP). Ticrynafen is also a substrate of CYP2C9


References

1. Manier, J W., et al., 1982. Hepatotoxicity associated with ticrynafen--a uricosuric diuretic. The American journal of gastroenterology. 77(6): 401-4. PMID: 7091125
2. Kerremans, A L., et al., 1982. Pharmacokinetic and pharmacodynamic studies of tienilic acid in healthy volunteers. European journal of clinical pharmacology. 22(6): 515-21. PMID: 7128663

Physical State :
Solid
Solubility :
Soluble in DMSO (~30 mg/ml), ethanol (~30 mg/ml), methanol (~1 mg/ml), and DMF (~30 mg/ml). Insoluble in water at 25 °C.
Storage :
Store at -20° C
Melting Point :
149° C
Boiling Point :
534.57° C at 760 mmHg (Predicted)
Density :
1.53 g/cm3 (Predicted)
Refractive Index :
n20D 1.63 (Predicted)
IC50 :
Aldose reductase: IC50 = 3.21 µM (rat)
Ki Data :
CYP2C10: Ki= 4.3 µM; CYP2C9: Ki= 4.3 µM (human)
pK Values :
pKa: 2.79 (Predicted), 3.32 (Predicted), pKb: -5 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
AG9300000
PubChem CID :
MDL Number :
MFCD00867339
EC Number :
254-826-3
Beilstein Registry :
1260086
SMILES :
C1=CSC(=C1)C(=O)C2=C(C(=C(C=C2)OCC(=O)O)Cl)Cl

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Kerremans Kerremans, AL. et al. (PubMed 7128663) developed a simple and reliable HPLC method for the determination of the cytochrome P450 inhibitor Ticrynafen and its alcoholic metabolite in plasma and urine. -SCBT Publication Review
Date published: 2015-07-03
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