TicrynafenA cytochrome P450 inhibitor

Ticrynafen (CAS 40180-04-9)

Ticrynafen | CAS 40180-04-9 is rated 5.0 out of 5 by 1.
  • y_2019, m_9, d_17, h_8
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.13
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_220253, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 145ms
  • REVIEWS, PRODUCT
Application: A cytochrome P450 inhibitor
CAS Number: 40180-04-9
Purity: >99%
Molecular Weight: 331.17
Molecular Formula: C13H8Cl2O4S
* Refer to Certificate of Analysis for lot specific data (including water content).
submit a review for this product and receive 15 cruzcredits

Ticrynafen is a heterocyclic derivative of phenoxyacetic acid which inhibits cytochrome P450 (CYP). Ticrynafen is also a substrate of CYP2C9


References

1. Manier, J W., et al., 1982. Hepatotoxicity associated with ticrynafen--a uricosuric diuretic. The American journal of gastroenterology. 77(6): 401-4. PMID: 7091125
2. Kerremans, A L., et al., 1982. Pharmacokinetic and pharmacodynamic studies of tienilic acid in healthy volunteers. European journal of clinical pharmacology. 22(6): 515-21. PMID: 7128663

Physical State :
Solid
Solubility :
Soluble in DMSO (~30 mg/ml), ethanol (~30 mg/ml), methanol (~1 mg/ml), and DMF (~30 mg/ml). Insoluble in water at 25 ºC.
Storage :
Store at -20° C
Melting Point :
149° C
Boiling Point :
534.57° C at 760 mmHg (Predicted)
Density :
1.53 g/cm3 (Predicted)
Refractive Index :
n20D 1.63 (Predicted)
IC50 :
Aldose reductase: IC50 = 3.21 µM (rat)
Ki Data :
CYP2C10: Ki= 4.3 µM; CYP2C9: Ki= 4.3 µM (human)
pK Values :
pKa: 2.79 (Predicted), 3.32 (Predicted), pKb: -5 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
AG9300000
PubChem CID :
38409
MDL Number :
MFCD00867339
EC Number :
254-826-3
Beilstein Registry :
1260086
SMILES :
C1=CSC(=C1)C(=O)C2=C(C(=C(C=C2)OCC(=O)O)Cl)Cl

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 50ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Kerremans Kerremans, AL. et al. (PubMed 7128663) developed a simple and reliable HPLC method for the determination of the cytochrome P450 inhibitor Ticrynafen and its alcoholic metabolite in plasma and urine. -SCBT Publication Review
Date published: 2015-07-03
  • y_2019, m_9, d_17, h_8
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.13
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_220253, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 10ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.