Ticrynafen is a heterocyclic derivative of phenoxyacetic acid which inhibits cytochrome P450 (CYP). Ticrynafen is also a substrate of CYP2C9
1. Manier, J W., et al., 1982. Hepatotoxicity associated with ticrynafen--a uricosuric diuretic. The American journal of gastroenterology. 77(6): 401-4. PMID: 7091125
2. Kerremans, A L., et al., 1982. Pharmacokinetic and pharmacodynamic studies of tienilic acid in healthy volunteers. European journal of clinical pharmacology. 22(6): 515-21. PMID: 7128663
Soluble in DMSO (~30 mg/ml), ethanol (~30 mg/ml), methanol (~1 mg/ml), and DMF (~30 mg/ml). Insoluble in water at 25 ºC.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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KerremansKerremans, AL. et al. (PubMed 7128663) developed a simple and reliable HPLC method for the determination of the cytochrome P450 inhibitor Ticrynafen and its alcoholic metabolite in plasma and urine. -SCBT Publication Review
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