Ticlopidine hydrochloride is a platelet aggregation inhibitor capable of inducing apoptosis in various cancer cell lines by antagonizing the P2Y12 receptor, which is responsible for initiating the signal transduction that causes platelets to aggregate.
Chen WH, Yin HL, Chang YY et al. Kaohsiung J Med Sci. 13:589-97 (1997). Ma L, Elliott SN, Cirino G et al. Proc Natl Acad Sci U S A. 98:6470-5 (2001).
Soluble in methanol, water (4 mg/ml at 25° C), ethanol (1 mg/ml at 25° C), and DMSO (1 mg/ml at 25° C).
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Park MS; et alPark MS; et al. (PubMed ID: 26327247) determined that Ticlopidine Hydrochloride blocks the effect of angiogenic vascular endothelial growth factor by reducing the human umbilical vein endothelial cells, in frog embryos. -SCBT Publication Review
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