TIC10A small molecule that induces TRAIL in a p53-independent manner

TIC10 (CAS 41276-02-2)

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Synonym: TRAIL-inducing compound 10
Application: A small molecule that induces TRAIL in a p53-independent manner
CAS Number: 41276-02-2
Molecular Weight: 386.49
Molecular Formula: C24H26N4O
* Refer to Certificate of Analysis for lot specific data (including water content).
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TIC10 (TRAIL-inducing compound 10) is an orally active, stable and potent small molecule that has been shown to transcriptionally induce TRAIL and TRAIL-mediated cell death in a p53-independent manner. TIC10 also activates the gene Foxo3a by dually inactivating Akt and ERK. TIC10 crosses the blood-brain barrier and is expected to be useful as an antitumor therapeutic agent.


References

J.E. Allen et al. Dual Inactivation of Akt and ERK by TIC10 Signals Foxo3a Nuclear Translocation, TRAIL Gene Induction, and Potent Antitumor Effects. Sci. Transl. Med. 2013, 5, 171ra17.

J.E. Allen. Efficacy and mechanistic evaluation of TIC10, a novel antitumor agent. Dissertation Univ. Pennsylvania 2012.

Physical State :
Solid
Solubility :
Soluble in DMSO (2 mg/ml).
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
336423
SMILES :
CC1=CC=CC=C1CN2C3=C(CN(CC3)CC4=CC=CC=C4)C(=O)N5C2=NCC5

Download SDS (MSDS)

Certificate of Analysis

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