ThymoquinoneA phytochemical that inhibitis tumor angiogenesis

Thymoquinone (CAS 490-91-5)

Thymoquinone | CAS 490-91-5 is rated 5.0 out of 5 by 1.
  • y_2019, m_9, d_20, h_17
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.13
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_215986, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 91ms
  • REVIEWS, PRODUCT
Synonym: 2-Isopropyl-5-methyl-1,4-benzoquinone
Application: A phytochemical that inhibitis tumor angiogenesis
CAS Number: 490-91-5
Purity: ≥98%
Molecular Weight: 164.20
Molecular Formula: C10H12O2
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Thymoquinone is a phytochemical compound that acts as an angiogenesis inhibitor. Possesses potential analgesic, anticonvulsant, and anticancer properties in vitro.


References

1. Kundu, Juthika., et al., 2014. Thymoquinone induces heme oxygenase-1 expression in HaCaT cells via Nrf2/ARE activation: Akt and AMPKα as upstream targets. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 65(): 18-26. PMID: 24355171
2. Aycan, Ilker Öngüç., et al., 2014. Thymoquinone treatment against acetaminophen-induced hepatotoxicity in rats. International journal of surgery (London, England). (): . PMID: 24389315
3. Ashour, Abdelkader E., et al., 2014. Thymoquinone suppression of the human hepatocellular carcinoma cell growth involves inhibition of IL-8 expression, elevated levels of TRAIL receptors, oxidative stress and apoptosis. Molecular and cellular biochemistry. (): . PMID: 24399465
4. Khan, Masood A., et al., 2014. Protective effect of thymoquinone on glucose or methylglyoxal-induced glycation of superoxide dismutase. International journal of biological macromolecules. 65C(): 16-20. PMID: 24412154
5. Siveen, Kodappully Sivaraman., et al., 2014. Thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of NF-κB regulated gene products in multiple myeloma xenograft mouse model. Oncotarget. (): . PMID: 24504138

Appearance :
Powder or crystalline or crystalline powder or chunks
Physical State :
Solid
Solubility :
Soluble in ether, alcohol, water (0.87 mg/ml at 25° C), chloroform, and methanol.
Storage :
Store at room temperature
Melting Point :
45-47° C (lit.)
Boiling Point :
230-232° C (lit.)
Density :
1.07 g/cm3 (Predicted)
Refractive Index :
n20D 1.51 (Predicted)
IC50 :
HL-60: IC50 = 28 µM (human); HFF: IC50 = 33 µM (human); HT-29: IC50 = 47 µM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
GU5330000
PubChem CID :
10281
MDL Number :
MFCD00001602
EC Number :
207-721-1
Beilstein Registry :
1939047
SMILES :
CC1=CC(=O)C(=CC1=O)C(C)C

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

Thymoquinone  Product Citations

See how others have used Thymoquinone. Click on the entry to view the PubMed entry .

Citations 1 to 4 of 4 total

PMID: # 25719309  Periyanayagam, S. et al. 2015. Journal of basic and clinical physiology and pharmacology. 26: 623-32.

PMID: # 26171893  Khan, MS. et al. 2015. Phytotherapy research : PTR. 29: 1610-5.

PMID: # 25709021  Khan, MA. et al. 2015. International journal of biological macromolecules. 76: 203-8.

PMID: # 22206670  Lei, X. et al. 2012. Biochemical and biophysical research communications. 417: 864-8.

Citations 1 to 4 of 4 total

I am planing to use this product on some cancer cells to see its effect, since it is insoluble in water or PBS, how can I dissolve it i=on condition that the solvent do not affect on cells?

Asked by: Waleedvacsera
Thank you for your question. This biochemical is soluble in ether, alcohol, water (0.87 mg/ml at 25˚C), chloroform, and methanol. If you have any further questions, please contact our European Technical Service team. You can reach them by phone at Toll Free: +49 6221 4503 0, by email at: europe@scbt.com or by live chat directly on our website, www.scbt.com
Answered by: Tech Service
Date published: 2017-09-09

I've bought 1gram tmq from Santa Cruz. I plan to dissolve 10mg of thymoquinone in 100%DMSO 610microlitre (to make 100mM stock solution) &I want to make serial dilution to get 0.1% dmso by adding endotoxin free water or pbs ph7.4. Is it possible?thank you

Asked by: Vina
Thank you for your question. The solubility of this chemical, Thymoquinone: sc-215986, in DMSO is 10mg/mL. It would be difficult to dissolve 10mg in 610 microlitre DMSO. Thymoquinone is insoluble in water. It is not recommended to add water or PBS because the chemical may separate out.
Answered by: Technical Support
Date published: 2017-07-22

Is this compound soluble in DMSO?

Asked by: two2igm05
Thank you for your question. Thymoquinone, sc-215986, is soluble in DMSO at a concentration of 10mg/ml.
Answered by: TechService7
Date published: 2017-01-04
  • y_2019, m_9, d_21, h_19CST
  • bvseo_bulk, prod_bvqa, vn_bulk_2.0.13
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_3
  • loc_en_US, sid_215986, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 158ms
  • QUESTIONS, PRODUCT
Rated 5 out of 5 by from Alkharfy Alkharfy, KM. et al. (PubMed 26285172) reported that the phytochemical Thymoquinone modulates nitric oxide production and improves organ dysfunction of sepsis. -SCBT Publication Review
Date published: 2015-02-28
  • y_2019, m_9, d_20, h_17
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.13
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_215986, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 9ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.