ThiostreptonA protein synthesis-inhibiting antibiotic

Thiostrepton (CAS 1393-48-2)

Thiostrepton | CAS 1393-48-2 is rated 5.0 out of 5 by 1.
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Synonym: Bryamycin; Thiactin; Alaninamide
Application: A protein synthesis-inhibiting antibiotic
CAS Number: 1393-48-2
Molecular Weight: 1664.88
Molecular Formula: C72H85N19O18S5
* Refer to Certificate of Analysis for lot specific data (including water content).
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Thiostrepton is a cyclic peptide antibiotic, densely packed with thiazoles and other structurally intriguing moieties. Thiostrepton exhibits antibiotic activity through blockade of ribosome turnover after an elongation step in protein synthesis by inhibiting both the dissociation of elongation factor G (EF-G) from the ribosome and the release of inorganic phosphate from EF-G following GTP hydrolysis. Thiostrepton is also described to show efficacy against cancer cell growth through downregulation of the forkhead box M1 (FOXM1) transcription factor, commonly overexpressed in many malignancies. Thiostrepton is an inhibitor of FOXM1.


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Appearance :
Physical State :
Derived From :
Streptomyces azureus
Solubility :
Soluble in DMSO (10 mg/ml), chloroform (10 mg/ml), dioxane, pyridine, glacial acetic acid, and DMF. Insoluble in water.
Storage :
Store at -20° C
Melting Point :
246-256° C
Density :
1.64 g/cm3 (Predicted)
Refractive Index :
n20D 1.77 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
PubChem CID :
Merck Index :
14: 9364
MDL Number :
EC Number :

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Thiostrepton  Product Citations

See how others have used Thiostrepton. Click on the entry to view the PubMed entry .

Citations 1 to 5 of 5 total

PMID: # 31042405  Van der Feen, DE.|Kurakula, K.|Tremblay, E.|Boucherat, O.|Bossers, GP.|Szulcek, R.|Bourgeois, A.|Lampron, MC.|Habbout, K.|Martineau, S.|Paulin, R.|Kulikowski, E.|Jahagirdar, R.|Schalij, I.|Bogaard, HJ.|Bartelds, B.|Provencher, S.|Berger, RMF.|Bonnet, S.|Goumans, MJ.| et al. 2019. Am. J. Respir. Crit. Care Med.

PMID: # 29290032  Bourgeois, A.|Lambert, C.|Habbout, K.|Ranchoux, B.|Paquet-Marceau, S.|Trinh, I.|Breuils-Bonnet, S.|Paradis, R.|Nadeau, V.|Paulin, R.|Provencher, S.|Bonnet, S.|Boucherat, O.| et al. 2018. J. Mol. Med. 96: 223-235.

PMID: # 28286049  Shirakawa, J. et al. 2017. Cell Metab. 25: 868-882.e5.

PMID: # 28692634  Westhoff, GL.|Chen, Y.|Teng, NNH.| et al. 2017. Int. J. Gynecol. Cancer. 27: 1602-1609.

PMID: # 25897210  Chan-On, W. et al. 2015. Drug design, development and therapy. 9: 2033-47.

Citations 1 to 5 of 5 total

What are the storage conditions once dissolved in DMSO?

Asked by: chemsd02
Thank you for your question. sc-203412 (Thiostrepton, CAS 1393-48-2) should be stored at -20ºC and protected from light and moisture. The shelf life once post reconstitution is about 3 months.
Answered by: Chemical Support 10
Date published: 2017-03-09
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Rated 5 out of 5 by from Sandu Sandu, C. et al. (PubMed 26033448) demonstrated a novel mechanism of proteasome inhibition mediated by Thiostrepton, a cyclic peptide antibiotic. Thiostrepton binds covalently to Rpt subunits of the 19S regulatory particle and forms bridges with a proteasome substrate. -SCBT Publication Review
Date published: 2015-04-17
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