ThiosildenafilA PDE5A inhibitor

Thiosildenafil (CAS 479073-79-5)

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Synonym: 5-[2-Ethoxy-5-[(4-methyl-1-piperazinyl)sulfonyl]phenyl]-1,6-dihydro-1-methyl-3-propyl-7H-pyrazolo[4,3-d]pyrimidine-7-thione; 1-[[3-(4,7-Dihydro-1-methyl-3-propyl-7-thioxo- 1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine
Application: A PDE5A inhibitor
CAS Number: 479073-79-5
Purity: 98%
Molecular Weight: 490.64
Molecular Formula: C22H30N6O3S2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Thiosildenafil is a novel pyrazolopyrimidinethione analog of sildenafil (sc-338584) which acts as a PDE5A inhibitor.


References

1. Blok-Tip, L., et al., 2004. Structure elucidation of sildenafil analogues in herbal products. Food additives and contaminants. 21(8): 737-48. PMID: 15370823
2. Liang, Qionglin., et al., 2006. Rapid and reliable determination of illegal adulterant in herbal medicines and dietary supplements by LC/MS/MS. Journal of pharmaceutical and biomedical analysis. 40(2): 305-11. PMID: 16174560

Physical State :
Solid
Solubility :
Soluble in chloroform, methanol, DMSO (~5 mg/ml), DMF (~16 mg/ml), and 1: 3 solution of DMF: PBS (pH 7.2) (~0.25 mg/ml).
Storage :
Store at 4° C
Melting Point :
172-174° C
Boiling Point :
676.06° C at 760 mmHg (Predicted)
Density :
1.40 g/cm3 (Predicted)
Refractive Index :
n20D 1.68 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
10228242
MDL Number :
MFCD11977921
SMILES :
CCCC1=NN(C2=C1NC(=NC2=S)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)C)OCC)C

Download SDS (MSDS)

Certificate of Analysis

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