Thioridazine HydrochlorideA D2DR, D4DR, and calcium channel protein inhibitor

Thioridazine Hydrochloride (CAS 130-61-0)

Thioridazine Hydrochloride | CAS 130-61-0 is rated 5.0 out of 5 by 1.
  • y_2019, m_12, d_9, h_12
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.3
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_201149, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 158ms
  • REVIEWS, PRODUCT
5
1
4
0
3
0
2
0
1
0
Synonym: 10-[2-(1-Methyl-2-piperidyl)ethyl]-2-(methylthio)-10H-phenothiazine hydrochloride
Application: A D2DR, D4DR, and calcium channel protein inhibitor
CAS Number: 130-61-0
Purity: ≥98%
Molecular Weight: 407.0
Molecular Formula: C21H26N2S2•HCl
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Thioridazine·HCl is a calcium channel protein inhibitor as well as a D2DR/D4DR inhibitor. It is an intercalating agent for analyzing the integrity of double stranded DNA by using the square-wave voltammetry.


References

1. Swanson, D.W. 1961. Am J Psychiatry. 117: 834-835. PMID: 13774226
2. Vonvoigtlander, P.F., et al. 1975. J. Pharmacol. Exp. Ther. 193: 88-94. PMID: 166158
3. Hine, B., et al. 1979. Experientia. 35: 1631-1632. PMID: 520480
4. Snyder, S.H., et al. 1985. N. Engl. J. Med. 313: 995-1002. PMID: 2413355
5. Roth, B.L., et al. 1995. Psychopharmacology. 120: 365-368. PMID: 8524985

Physical State :
Solid
Solubility :
Soluble in water (75 mM), DMSO (100 mM), chloroform, ethanol, and methanol.
Storage :
Store at room temperature
Melting Point :
161-163° C
Ki Data :
Cloned rat dopamine D4 receptor: Ki= <20 nM
pK Values :
pKb: 9.84 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
SP2275000
PubChem CID :
66062
Merck Index :
14: 9359
MDL Number :
MFCD00012655
EC Number :
204-992-8
SMILES :
CN1CCCCC1CCN2C3=CC=CC=C3SC4=C2C=C(C=C4)SC.Cl

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 67ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Kristiansen JE; et al Kristiansen JE; et al. (PubMed ID: 26415662) Determined that small doses of Thioridazine Hydrochloride caused cytotoxicity in tubercle bacilli in lung macorphages. -SCBT Publication Review
Date published: 2015-07-19
  • y_2019, m_12, d_9, h_12
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.3
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_201149, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 3ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.