Thiocolchicoside CAS: 602-41-5
MF: C27H33NO10S
MW: 563.6
A GABAA receptor antagonist.

Thiocolchicoside (CAS 602-41-5)

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Alternate Names: 2-Demethoxy-2-glucosidoxythiocolchicine
Application: Thiocolchicoside is a GABAA receptor antagonist
CAS Number: 602-41-5
Purity: >95%
Molecular Weight: 563.6
Molecular Formula: C27H33NO10S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Thiocolchicoside is a small molecule muscle relaxant and anti-inflammatory agent, shown to function as a competitive GABAA (gamma-aminobutyric acid type A) receptor antagonist. Thiocolchicoside is also shown to inhibit strychnine-sensitive GlyR (glycine receptors)with lower potency than GABAA, and to inhibit human AChR (nicotinic acetylcholine receptors) with very low relative affinity.


References

1. Sechi, G., et al. 2003. Seizure. 12: 508-515. PMID: 12967581
2. Carta, M., et al. 2006. Neuropharmacology. 51: 805-815. PMID: 16806306
3. Mascia, M.P., et al. 2007. Eur. J. Pharmacol. 558: 37-42. PMID: 17234181

Physical State :
Solid
Derived From :
Semisynthetic.
Solubility :
Soluble in water, and 100% ethanol. Insoluble in ether, and acetone.
Storage :
Store at -20° C
Melting Point :
220° C (dec.)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
Merck Index :
14: 9324
SMILES :
CC(=O)NC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)SC)OC)OC)O[[email protected]]4[[email protected]@H]([[email protected]]([[email protected]@H]([[email protected]](O4)CO)O)O)O

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Certificate of Analysis

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