ThiazovivinA ROCK inhibitor that is also known to enhance the efficiency of fibroblast reprogramming
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Thiazovivin (CAS 1226056-71-8)

Thiazovivin | CAS 1226056-71-8 is rated 5.0 out of 5 by 1.
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See product citations (7)
Synonym: N-Benzyl-[2-(pyrimidin-4-yl)amino]thiazole-4-carboxamide
Application: A ROCK inhibitor that is also known to enhance the efficiency of fibroblast reprogramming
CAS Number: 1226056-71-8
Purity: ≥98%
Molecular Weight: 311.36
Molecular Formula: C15H13N5OS
* Refer to Certificate of Analysis for lot specific data (including water content).
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Thiazovivin significantly enhances the efficiency of fibroblast reprogramming to generate induced pluripotent stem cells when used in combination with SB 431542 (sc-204265) and PD 0325901 (sc-205427). It is known to improve the survival of human embryonic stem cells upon trypsinization. It also behaves as an inhibitor of Rho-associated kinase (ROCK).

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), water (<1 mg/ml) at 25 °C, and ethanol (5 mg/ml) at 25 °C.
Storage :
Store at -20° C
Density :
1.38 g/cm3 (Predicted)
Refractive Index :
n20D 1.69 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
46209426
MDL Number :
MFCD16495823
SMILES :
C1=CC=C(C=C1)CNC(=O)C2=CSC(=N2)NC3=NC=NC=C3

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Thiazovivin  Product Citations

See how others have used Thiazovivin. Click on the entry to view the PubMed entry .

Citations 1 to 7 of 7 total

PMID: # 30742267  Mae, SI.|Ryosaka, M.|Osafune, K.| et al. 2019. Methods Mol. Biol. 1926: 117-123.

PMID: # 29158085  Mae, SI.|Ryosaka, M.|Toyoda, T.|Matsuse, K.|Oshima, Y.|Tsujimoto, H.|Okumura, S.|Shibasaki, A.|Osafune, K.| et al. 2018. Biochem. Biophys. Res. Commun. 495: 954-961.

PMID: # 29804836  Chen, L. et al. 2018. Cell. 174: 218-230.e13.

PMID: # 28273465  Xia, N. et al. 2017. Cell Rep. 18: 2533-2546.

PMID: # 26381699  Phadnis, SM. et al. 2015. Sci Rep. 5: 14209.

PMID: # 25463491  Chien, Y. et al. 2015. Acta Biomater. 13: 228-44.

PMID: # 25668102  Chiang, CH. et al. 2015. Cell Transplant. 24: 541-59.

Citations 1 to 7 of 7 total
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Rated 5 out of 5 by from Park et al Park et al. (PubMed ID 26307658) found that Thiazovivin, a rho kinase inhibitor, promoted cell adhesion and the expression of pluripotency marker genes. -SCBT Publication Review
Date published: 2015-05-02
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