ThapsigarginAn inducer of stored Ca2+ release

Thapsigargin (CAS 67526-95-8)

Thapsigargin | CAS 67526-95-8 is rated 5.0 out of 5 by 2.
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Application: An inducer of stored Ca2+ release
CAS Number: 67526-95-8
Purity: ≥99%
Molecular Weight: 650.75
Molecular Formula: C34H50O12
* Refer to Certificate of Analysis for lot specific data (including water content).
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Thapsigargin is a cell-permeable sesquiterpene lactone found in the roots of Thapsia garganica. It is a tumor promoter and induces the release of intracellular stored Ca2+ without hydrolysis of inositolphospholipids via inhibition of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA; IC50=30 nM). It may be used to distinguish between discrete intracellular Ca2+ pools. Thapsigargin-induced tumor promotion and down regulation of the EGF receptor is independent of protein kinase C activation.


References

1. Fujiki, H., et al. 1986. Carcinogenesis. 7: 707-710. PMID: 2870823
2. Takemura, H., et al. J. Biol. Chem. 264: 12266-12271. PMID: 2663854
3. Thastrup, O., et al. 1990. Proc. Natl. Acad. Sci. U.S.A. 87: 2466-2470. PMID: 2138778
4. Papp, B., et al. 1991. J. Biol. Chem. 266: 14593-14596.PMID: 1830588
5. Bian, J., et al. 1991. J. Biol. Chem. 266: 8801-8806. PMID: 1827436
6. Jackson, T.R., et al. 1988. Biochem. J. 253: 81-86. PMID: 3138987
7. Takishima, K., et al. 1988. Biochem. Biophys. Res. Commun. 157: 740-746. PMID: 3202876
8. Friedman, B., et al. 1989. Proc. Natl. Acad. Sci. U.S.A. 86: 812-816.PMID: 2492663

Usage :
USE CAUTION – product is a tumor promoter. Solutions may lose activity after one week. For long-term storage, dissolve in acetone or ethanol, aliquot and evaporate solvent to dryness with a stream of nitrogen or argon.
Appearance :
Film
Physical State :
Solid
Solubility :
Soluble in DMSO (20 mg/ml), ethanol (20 mg/ml), and acetone.
Storage :
Store at -20° C
Boiling Point :
~699.6° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.54 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
446378
Merck Index :
14: 9272
MDL Number :
MFCD00083511
SMILES :
CCCCCCCC(=O)O[C@H]1[C@H]2C(=C([C@@H]1OC(=O)/C(=C\C)/C)C)[C@H]3[C@]([C@H](C[C@]2(C)OC(=O)C)OC(=O)CCC)([C@](C(=O)O3)(C)O)O

Download SDS (MSDS)

Certificate of Analysis

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Thapsigargin  Product Citations

See how others have used Thapsigargin. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 47 total

PMID: # 31032369  Radzik, T. et al. 2019. Biomed Res Int. 2019: 9616248.

PMID: # 30196486  2019. Biol Trace Elem Res. 188: 2-10.

PMID: # 28497200  Tibullo, D.|Giallongo, C.|Puglisi, F.|Tomassoni, D.|Camiolo, G.|Cristaldi, M.|Brundo, MV.|Anfuso, CD.|Lupo, G.|Stampone, T.|Li Volti, G.|Amenta, F.|Avola, R.|Bramanti, V.| et al. 2018. Mol. Neurobiol. 55: 3344-3350.

PMID: # 28536105  Ramírez-Peinado, S. et al. 2017. J. Cell. Sci. 130: 2251-2265.

PMID: # 29118074  Baumann, J. et al. 2017. Mol. Biol. Cell.

PMID: # 28981087  van Raam, BJ. et al. 2017. Cell Death Dis. 8: e3069.

PMID: # 29074567  Gendarme, M. et al. 2017. Mol. Biol. Cell.

PMID: # 27587023  Kobylewski, SE. et al. 2017. Biol Trace Elem Res. 176: 278-293.

PMID: # 26930712  Tibullo, D.|Barbagallo, I.|Giallongo, C.|Vanella, L.|Conticello, C.|Romano, A.|Saccone, S.|Godos, J.|Di Raimondo, F.|Li Volti, G.| et al. 2016. Oncotarget. 7: 28868-80.

PMID: # 26631534  Zhong, W. et al. 2016. Neuropharmacology. 103: 195-210.

Citations 1 to 10 of 47 total

How long can this product be stored in DMSO solution at -20°C or -80°C????

Asked by: Rasoul
We do not recommend storing this in solution.
Answered by: Technical Support
Date published: 2019-09-11

How long can this product be stored in DMSO solution at -20°C or -80°C?

Asked by: mreyn
Thank you for your question. Solutions may lose activity after one week. For long-term storage, dissolve in acetone or ethanol, aliquot and evaporate solvent to dryness with a stream of nitrogen or argon. The product should be stored at -20 °C.
Answered by: SCBT Heidelberg Support
Date published: 2019-01-07

ld 50 of thapsigargin

Asked by: sekhar
Thank you for your question. Unfortunately, the LD 50 of Thapsigargin (CAS 67526-95-8) is not known.
Answered by: Technical Support
Date published: 2017-03-14

What is the expected appearance of this product?

Asked by: chemicalsmg
Thank you for your question. Thapsigargin: sc-24017 is expected to be a clear colorless film.
Answered by: Chemical Support 3
Date published: 2017-03-09

Is this soluble in acetonitrile?

Asked by: chemicalsmg
Thank you for your question. Thapsigargin: sc-24017 is soluble in acetonitrile at 10 mg/ml.
Answered by: Chemical Support 3
Date published: 2017-03-09

Can this product be stored in solution?

Asked by: hawkeye11
Thank you for your question. We do not recommend storing this chemical in a solution. However, it is partially soluble in DMSO, from 5-20 mg/ml. Please contact Technical Service if you have further questions concerning this product.
Answered by: Tech Service 9
Date published: 2018-11-18
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Rated 5 out of 5 by from Working out great Working out great!
Date published: 2015-01-19
Rated 5 out of 5 by from Hamamura Hamamura, et al. (PubMed ID 18470663) explained that thapsigargin was dissolved in DMSO prior to use in culture. -SCBT QC
Date published: 2015-01-07
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