TGFβ Receptor I/TGFBR1 Antibody (B-7) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
raised against amino acids 26-125 mapping within an extracellular domain of TGFβ RI of human origin
recommended for detection of TGFβ RI of human origin by WB, IP, IF and ELISA
m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for TGFβ Receptor I/TGFBR1 Antibody (B-7) for WB applications. These reagents are now offered in bundles with TGFβ Receptor I/TGFBR1 Antibody (B-7) (see ordering information below).
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
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Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
A total of three members of the TGFβ family, TGFβ1, TGFβ2 and TGFβ3, have been identified in mammals. Each is synthesized as a latent precursor that is subsequently cleaved forming the 112 amino acid growth factor which becomes active upon dimerization. TGFβs mediate their activity by high affinity binding to the type II receptor transmembrane protein with a cytoplasmic serine-threonine kinase domain. For signaling growth inhibition and early gene responses, TGFβ RII requires both its kinase activity and its association with a TGFβ-binding protein, designated TGFβ receptor type-1 (TGFβ RI). TGFβ RI is a 503 amino acid single-pass type I membrane protein that is expressed ubiquitously and, with TGFβ RII, functions as a receptor for TGFβ. Defects in the gene encoding TGFβ RI are the cause of aortic aneurysm familial thoracic type 5 (AAT5), Loeys-Dietz syndrome type 2A (LDS2A) and Loeys-Dietz syndrome type 1A (LDS1A).
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