tetranor-12(R)-HETE (CAS 135271-51-1)

Tetranor-12(R)-HETE, registered under CAS number 135271-51-1, represents a metabolically processed form of 12(R)-HETE, characterized by the removal of four carbon atoms from the carboxylic end of the parent molecule. This transformation results in a shortened lipid mediator that retains the hydroxyl group at the twelfth carbon in the R configuration. Tetranor-12(R)-HETE is particularly notable for its role in modulating intracellular signaling pathways that influence cellular responses to oxidative stress and environmental changes. In biochemical research, this compound is utilized to study the finer aspects of lipid metabolism and its impact on cell signaling dynamics. The specific actions of tetranor-12(R)-HETE include the modulation of enzymatic activities and the interaction with specific lipid receptors, which are crucial for understanding the regulation of cellular processes such as inflammation, cell migration, and apoptosis. Research involving tetranor-12(R)-HETE provides valuable insights into the complex pathways by which lipid mediators influence cellular behavior, shedding light on the mechanisms by which cells maintain homeostasis and adapt to physiological challenges. This understanding is vital for advancing the knowledge of cellular biochemistry and the complex network of signaling molecules that orchestrate cellular function and response.