TetrandrineA calcium channel protein inhibitor

Tetrandrine (CAS 518-34-3)

Tetrandrine | CAS 518-34-3 is rated 5.0 out of 5 by 2.
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Synonym: Fanchinine; Hanfangchin A; (1β)-6,6′,7,12-Tetramethoxy-2,2′-dimethyl-berbaman
Application: A calcium channel protein inhibitor
CAS Number: 518-34-3
Purity: ≥98%
Molecular Weight: 622.75
Molecular Formula: C38H42N2O6
* Refer to Certificate of Analysis for lot specific data (including water content).
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Tetrandrine is a calcium channel protein inhibitor. Tetrandrine blocks the L-type (IC50= 0.3-8 µM) and T-type (IC50= 2.5-20 µM) calcium channels. It is also a potent blocker of the Ca2+-activated K+ channel (Kd= 0.2 µM).


References

1. Kwan, C.Y. 1995. Clin Exp Pharmacol Physiol Suppl. 22: S297-S299. PMID: 9072399
2. Wang, G., et al. 1995. Life Sci. 56: 295-306. PMID: 7837929
3. Dworetzky, S.I., et al. 1996. J. Neurosci. 16: 4543-4550. PMID: 8764643

Physical State :
Solid
Solubility :
Soluble in DMSO, and ether. Insoluble in water.
Storage :
Store at room temperature
Melting Point :
219-222° C
Boiling Point :
~710.5° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.59 (Predicted)
Optical Activity :
α20/D 285°, c = 1 in CHCl3
IC50 :
L-type calcium channel: IC50 = 0.3-8 µM; T-type calcium channel: IC50 = 2.5-20 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
XE9350000
PubChem CID :
73078
Merck Index :
14: 9231
MDL Number :
MFCD08689909
Beilstein Registry :
877811
SMILES :
CN1CCC2=CC(=C3C=C2[C@@H]1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)C[C@H]6C7=C(O3)C(=C(C=C7CCN6C)OC)OC)OC)OC

Download SDS (MSDS)

Certificate of Analysis

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Tetrandrine  Product Citations

See how others have used Tetrandrine. Click on the entry to view the PubMed entry .

Citations 1 to 6 of 6 total

PMID: # 30893855  Zapatero-Belinchón, FJ.|Dietzel, E.|Dolnik, O.|Döhner, K.|Costa, R.|Hertel, B.|Veselkova, B.|Kirui, J.|Klintworth, A.|Manns, MP.|Pöhlmann, S.|Pietschmann, T.|Krey, T.|Ciesek, S.|Gerold, G.|Sodeik, B.|Becker, S.|von Hahn, T.| et al. 2019. Viruses. 11:

PMID: # 29942796  Lyu, W.|Deng, Z.|Sunkara, LT.|Becker, S.|Robinson, K.|Matts, R.|Zhang, G.| et al. 2018. Front Cell Infect Microbiol. 8: 191.

PMID: # 28529589  Qiu, W. et al. 2017. Oncol Lett. 13: 3734-3738.

PMID: # 28199837  Kilpatrick, BS. et al. 2017. Cell Rep. 18: 1636-1645.

PMID: # 26041296  Rathbun, JY. et al. 2015. J. Virol. 89: 8428-43.

PMID: # 24625982  Qiu, W. et al. 2014. Cell death & disease. 5: e1123.

Citations 1 to 6 of 6 total
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Rated 5 out of 5 by from It works excellent We used this product to treat tumor cells, and it works excellent!
Date published: 2017-05-05
Rated 5 out of 5 by from Tian Tian, Y. et al. (PubMed 26302866) reported that CYP3A5 mediates bioactivation and cytotoxicity of calcium channel protein inhibitor Tetrandrine. -SCBT Publication Review
Date published: 2015-05-20
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