TetrahydrouridineA CDD inhibitor which may prevent growth of CDA-expressing tumors

Tetrahydrouridine (CAS 18771-50-1)

Tetrahydrouridine | CAS 18771-50-1 is rated 5.0 out of 5 by 1.
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Synonym: 3,4,5,6-Tetrahydrouridine; THU
Application: A CDD inhibitor which may prevent growth of CDA-expressing tumors
CAS Number: 18771-50-1
Purity: ≥80%
Molecular Weight: 248.23
Molecular Formula: C9H16N2O6
* Refer to Certificate of Analysis for lot specific data (including water content).
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Tetrahydrouridine is a potent competitive inhibitor of cytidine deaminase (CDD). It can inhibit cell proliferation by regulation of the cell cycle independent of cytidine deaminase (CDA) expression levels. Tetrahydrouridine may be useful for researching potential treatments for high CDA-expressing tumors.


References

Yusa, K., et al. 1995. Biochem. Biophys. Res. Commun. 206, 486. Bouffard, D.Y., et al. 1993. Biochem Pharmacol. 45, 1857. Laliberte, J., et al. 1992. Cancer Chemotherap. Pharmacol. 30, 7. Riva, C., et al. 1992. Chemotherapy 38, 358. Yusa, K., et al. 1992. J. Biol. Chem. 267, 16848. Hanze, A.R. 1967. J. Am. Chem. Soc. 89, 6720

Physical State :
Solid
Solubility :
Soluble in water (200 mg/ml), and methanol.
Storage :
Store at -20° C
Melting Point :
205.73° C (Predicted)
Boiling Point :
~668.6° C at 760 mmHg (Predicted)
Density :
~1.6 g/cm3 (Predicted)
Refractive Index :
n20D 1.63 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
UW5798980
PubChem CID :
29243
Beilstein Registry :
0752319
SMILES :
C1CN(C(=O)NC1O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O

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Certificate of Analysis

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Tetrahydrouridine  Product Citations

See how others have used Tetrahydrouridine. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 30926081  Savona, MR.|Odenike, O.|Amrein, PC.|Steensma, DP.|DeZern, AE.|Michaelis, LC.|Faderl, S.|Harb, W.|Kantarjian, H.|Lowder, J.|Oganesian, A.|Azab, M.|Garcia-Manero, G.| et al. 2019. Lancet Haematol. 6: e194-e203.

Citations 1 to 1 of 1 total

How is this chemical supposed to be handled safely? What kind of PPE is required? Thank you.

Asked by: LarisaAkop
Thank you for your question. Please refer to the Safety Datasheet (SDS) available for download on our website for this chemical. Sections 7 (HANDLING AND STORAGE) and 8 (EXPOSURE CONTROLS/PERSONAL PROTECTION). A link is provided below for your reference. http://datasheets.scbt.com/sds/aghs/en/sc-204339.pdf
Answered by: Technical Support
Date published: 2017-11-14

Hi there, can THU be safely kept at -40 deg C and for how long approx? Kind regards, Astrid

Asked by: Astrid
Thank you for your question. It is safe to store this chemical at - 40 degrees C. We do not characterize an expiration date for this chemical, but we do warranty it for one year from the date of purchase.
Answered by: Technical Support
Date published: 2017-09-07

What is the solubility of this product?

Asked by: hawkeye11
This chemical, Tetrahydrouridine (CAS 18771-50-1), is soluble in 100% methanol (~10 mg/ml).
Answered by: Chemical Support 1
Date published: 2017-03-15
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Rated 5 out of 5 by from Funamizu Funamizu, N. et al. (PubMed 22616006) found that Tetrahydrouridine (THU), a potent competitive inhibitor of cytidine deaminase, caused an increased rate of G1-phase occurrence while S-phase occurrence was diminished. Similarly, Ki-67 staining further supported that THU reduces cell proliferation and regulates cell cycle progression at the G1/S checkpoint by suppressing E2F1. -SCBT Publication Review
Date published: 2015-05-10
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