Tetraethylammonium chlorideA small molecule blocker of K+ channels

Tetraethylammonium chloride (CAS 56-34-8)

Tetraethylammonium chloride | CAS 56-34-8 is rated 5.0 out of 5 by 1.
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Synonym: Etamon chloride; TEA Chloride
Application: A small molecule blocker of K+ channels
CAS Number: 56-34-8
Purity: ≥98%
Molecular Weight: 165.70
Molecular Formula: C8H20ClN
* Refer to Certificate of Analysis for lot specific data (including water content).
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Tetraethylammonium chloride blocks K+ channels and nicotinic acetylcholine neurotransmission by blocking the receptor-mediated K+ currents. Tetraethylammonium chloride is an inhibitor of AChR.


References

1. Zucker, R.S. 1981. Brain Res. 208: 473-478. PMID: 6260296
2. Deshpande, S.S., et al. 1981. Brain Res. 225: 115-129. PMID: 6170390
3. Fan, S.F., et al. 1994. Biochem. Biophys. Res. Commun. 201: 24-29. PMID: 8198580
4. Tan, Y.P. and Llano, I. 1999. J. Physiol. 520: 65-78. PMID: 10517801
5. Raymond, V., et al. 1999. Neuroscience. 93: 1207-1218. PMID: 10473286
6. Niu, L.G., et al. 2008. Eur. J. Pharmacol. 580: 169-174. PMID: 17997400

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (50 mg/ml), chloroform, alcohol, ethanol, and acetone.
pH :
6.48 (10%)
Storage :
Store at room temperature
Melting Point :
37.5 (.4H2O)
IC50 :
Plasmodium falciparum: IC50 = 12.59 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
BS6125000
PubChem CID :
5946
Merck Index :
14: 9200
MDL Number :
MFCD00011828
EC Number :
200-267-5
Beilstein Registry :
3563247
SMILES :
CC[N+](CC)(CC)CC.[Cl-]

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Revah Revah, O. et al. (PubMed 26197082) used the K+ channel blocker Tetraethylammonium chloride to suggest that the outwardly rectifying current of layer 5 neocortical neurons is generated by cesium-permeable delayed rectifier potassium channels. -SCBT Publication Review
Date published: 2015-03-13
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