Date published: 2025-12-6

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tert-Butylamine (CAS 75-64-9)

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Alternate Names:
2-Amino-2-methylpropane
CAS Number:
75-64-9
Purity:
≥98%
Molecular Weight:
73.14
Molecular Formula:
C4H11N
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Tert-Butylamine is a primary aliphatic amine characterized by its branching structure, which plays a pivotal role in synthetic chemistry, particularly in the production of tert-butylamine derivatives used as intermediates in the synthesis of various compounds. Its mechanism of action revolves around its nucleophilic behavior, enabling it to participate in reactions with electrophiles, such as aldehydes and ketones, to form imines and enamines, which are intermediates in organic synthesis. This reactivity is exploited in research applications for the synthesis of polymers, dyes, pharmaceuticals, and agrochemicals, making tert-butylamine an invaluable reagent in the development of new materials and active compounds. Its volatility and basicity also make it a candidate for use as a catalyst or a catalyst precursor in various chemical reactions, further underscoring its versatility and importance in chemical research and industrial applications.


tert-Butylamine (CAS 75-64-9) References

  1. Preparation of N-acetyl, tert-butyl amide derivatives of the 20 natural amino acids.  |  Ekkati, AR., et al. 2010. Amino Acids. 38: 747-51. PMID: 19333720
  2. Structural transformations of sVI tert-butylamine hydrates to sII binary hydrates with methane.  |  Prasad, PS., et al. 2009. J Phys Chem A. 113: 11311-5. PMID: 19780602
  3. A systematic approach to the synthesis of androstane-based 3,17-dicarboxamides (homo- and mixed dicarboxamides) via palladium-catalyzed aminocarbonylation.  |  Kiss, M., et al. 2013. Steroids. 78: 693-9. PMID: 23499827
  4. Water-dispersible TiO2 nanoparticles via a biphasic solvothermal reaction method.  |  Mohan, R., et al. 2013. Nanoscale Res Lett. 8: 503. PMID: 24289214
  5. Blue-colored tert-butylamine clathrate hydrate.  |  Tani, A., et al. 2014. J Phys Chem B. 118: 13409-13. PMID: 25139225
  6. Towards Clathrates: Frozen States of Hydration of tert-Butylamine.  |  Dobrzycki, Ł., et al. 2015. Angew Chem Int Ed Engl. 54: 10138-44. PMID: 26177988
  7. Theoretical and Experimental Study on the Reaction of tert-Butylamine with OH Radicals in the Atmosphere.  |  Tan, W., et al. 2018. J Phys Chem A. 122: 4470-4480. PMID: 29659281
  8. Aromatic SNF-Approach to Fluorinated Phenyl tert-Butyl Nitroxides.  |  Tretyakov, E., et al. 2019. Molecules. 24: PMID: 31817965
  9. Effects of palm biodiesel and blends of biodiesel with organic acids on metals.  |  Baena, LM. and Calderón, JA. 2020. Heliyon. 6: e03735. PMID: 32395642
  10. Design, Synthesis and Biological Evaluation of Novel N-Alkyl-4-Methyl-2,2- Dioxo-1H-2λ6,1-Benzothiazine-3-Carboxamides as Promising Analgesics.  |  Ukrainets, I., et al. 2023. Med Chem. 19: 174-192. PMID: 35993458
  11. Kinetics of the Simplest Criegee Intermediate CH2OO Reaction with tert-Butylamine.  |  Chen, Y., et al. 2023. J Phys Chem A. 127: 2432-2439. PMID: 36913641
  12. Ion chromatography of amylamine and tert.-butylamine in pharmaceuticals.  |  Jagota, NK., et al. 1996. J Chromatogr A. 739: 343-9. PMID: 8765853

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

tert-Butylamine, 25 ml

sc-251137
25 ml
$20.00

tert-Butylamine, 100 ml

sc-251137A
100 ml
$22.00