Terbutaline Hemisulfate Salt (CAS 23031-32-5)

Terbutaline hemisulfate salt, a β2-adrenergic receptor agonist, has been a subject of substantial scientific research due to its mechanism of action and potential applications in studying respiratory physiology and pharmacology. Mechanistically, terbutaline exerts its effects by selectively activating β2-adrenergic receptors, which are primarily located in bronchial smooth muscle cells. Upon binding to these receptors, terbutaline stimulates the adenylyl cyclase enzyme, leading to an increase in intracellular cyclic adenosine monophosphate (cAMP) levels. Elevated cAMP levels activate protein kinase A (PKA), which phosphorylates various target proteins, including myosin light chain kinase (MLCK). Phosphorylation of MLCK results in the inhibition of myosin light chain (MLC) phosphorylation and subsequent smooth muscle relaxation. This relaxation leads to bronchodilation, making terbutaline a valuable tool in research related to bronchial smooth muscle physiology, airway responsiveness, and asthma pathogenesis. In addition to its bronchodilatory effects, terbutaline has been investigated for its potential role in modulating inflammatory responses in the airways, including the release of cytokines and chemokines from immune cells. Furthermore, research has explored the use of terbutaline in preclinical models to investigate the efficacy of novel agents targeting respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD). Overall, terbutaline hemisulfate salt serves as a valuable pharmacological tool in respiratory research, providing insights into the mechanisms underlying airway smooth muscle contraction and potential interventions for respiratory disorders.