Terbinafine hydrochlorideCAS: 78628-80-5
MF: C21H25N•HCl
MW: 327.9
A squalene monooxygenase inhibitor.

Terbinafine hydrochloride (CAS 78628-80-5)

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Synonym: trans-N-(6,6-Dimethyl-2-hepten-4-ylyl)-N-methyl-1-naphthylmethylamine hydrochloride
Application: A squalene monooxygenase inhibitor
CAS Number: 78628-80-5
Purity: ≥99%
Molecular Weight: 327.9
Molecular Formula: C21H25N•HCl
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Terbinafine·HCl a member of the allylamine class of antifungals, has been found to be a specific inhibitor of ergosterol synthesis via squalene epoxidase inhibition. Squalene epoxidase is an enzyme released by the dermatophyte fungi to break down Squalene, which interferes with cell membrane function and wall synthesis. Research has shown that Terbinafine also reduces the ability of fungal pathogens to generate reactive oxygen species, therefore it is noted as a free radical scavenger in vitro and could potentially contain anti-inflammatory activity in vivo. Additionally, Terbinafine has also been reported to suppress cell proliferation in vitro and in vivo through inhibition of DNA synthesis and apoptosis activation. It has also been noted that by pretreating of cells with a p21 specific antisense oligonucleotide the Terbinafine induced inhibition of cell growth can be reversed. Assays further demonstrated that Terbinafine also contains anti-angiogenic effects in chick embryo chorioallantoic membranes. We provide this product in the hydrochloride form.


1. Ryder, N.S. 1992. Br. J. Dermatol. 126: 2-7. PMID: 1543672
2. Favre, B., et al. 1997. Arch. Biochem. Biophys. 340: 265-269. PMID: 9143330
3. Sander, C.S., et al. 2002. Mycoses. 45: 152-155. PMID: 12100530
4. Ho, P.Y., et al. 2004. Int. J. Cancer. 111: 51-59. PMID: 15185342
5. Motavaze, K., et al. 2008. Iran. Biomed. J. 12: 55-58. PMID: 18392096

Appearance :
Physical State :
Solubility :
Soluble in methanol, ethanol (~30 mg/ml), methylene chloride, DMSO (~10 mg/ml), DMF (~10 mg/ml), and 1:2 solution of ethanol:PBS (pH 7.2) (0.3 mg/ml). Insoluble in water.
Storage :
Store at room temperature
Melting Point :
214° C
IC50 :
ergosterol synthesis at the stage of squalene epoxidation: IC50 = 30 nM (C. albicans)
Ki Data :
squalene epoxidase: Ki= 30 nM (Candida)
pK Values :
pKb: 6.92
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
PubChem CID :
Merck Index :
14: 9156
MDL Number :
EC Number :

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Certificate of Analysis

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Dear Sir/madam, If I order your product terbinafine, 1 gram, Order number: sc-200751A today, when will it be delivered? Best wishes, Maarten.

Asked by: Maarten1
Thank you for your question. Please contact our Customer Care Department to inquire about current product availability and shipping lead times for this chemical. Based on your location, please call our European Support office toll-free at 00800 4573 8000, email [email protected], or contact us by live chat.
Answered by: Technical Support
Date published: 2017-05-05
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