Tenovin-1An inhibitor of SIRT1 and SIRT2

Tenovin-1 (CAS 380315-80-0)

Tenovin-1 | CAS 380315-80-0 is rated 4.0 out of 5 by 1.
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Synonym: N-[(4-acetamidophenyl)carbamothioyl]-4-tert-butylbenzamide
Application: An inhibitor of SIRT1 and SIRT2
CAS Number: 380315-80-0
Purity: ≥98%
Molecular Weight: 369.50
Molecular Formula: C20H23N3O2S
* Refer to Certificate of Analysis for lot specific data (including water content).
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Tenovin-1 is a compound that belongs to the class of Tenovins, and inhibits SIRT1 and SIRT2. SIRT1 and SIRT2 are protein-deacetylases and are members of the NAD+-dependent class III histone deacetylases. Tenovin-1 has been shown to activate and elevate acetylated p53 levels, induce apoptosis in vitro, and acetylate histone H4. Studies report that the water solubility of Tenovin-1 was increased by attaching a solubilizing group to the R2 position, creating a new Tenovin, Tenovin-6 (sc-224296). Tenovin-1 is an activator of p21 and p53.


References

1. Brooks, C.L. and Gu, W. 2008. Cancer Cell. 13: 377-378. PMID: 18455119
2. Lain, S., et al. 2008. Cancer Cell. 13: 454-463. PMID: 18455128
3. Liu, T., et al. 2009. Cancer Res. 69: 1702-1705. PMID: 19244112

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO (0.25 mg/ml), and DMF (0.25 mg/ml).
Storage :
Store at -20° C
Refractive Index :
n20D 1.65 (Predicted)
IC50 :
SIRT2: IC50 = ~10 µM
pK Values :
pKa: 9.09 (Predicted), pKb: 0.68 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
1013376
MDL Number :
MFCD02914760
SMILES :
CC(=O)NC1=CC=C(C=C1)NC(=S)NC(=O)C2=CC=C(C=C2)C(C)(C)C

Download SDS (MSDS)

Certificate of Analysis

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Rated 4 out of 5 by from An increase in p21 protein expression was An increase in p21 protein expression was observed by WB when comparing Tenovin-1 treated MCF7 cells with those that have not been treated. -SCBT QC
Date published: 2015-05-01
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