Telmisartan is an angiotensin II receptor blocker (ARB) that has high affinity for the angiotensin II receptor type 1 (AT1). Telmisartan interferes with the binding of angiotensin II to AT1 receptors in vascular smooth muscle and thus inhibits the vasoconstricting action of angiotensin II. Additionally, telmisartan is a selective modulator of peroxisome proliferator-activated receptor gamma (PPARγ), an essential regulator of insulin and glucose metabolism. Therefore, telmisartan is useful for studying hypertension.
1. Wienen, W., et al. 1993. Br. J. Pharmacol. 110: 245-252. PMID: 8220885 2. McClellan, K.J., et al. 1998. Drugs. 56: 1039-46. PMID: 9878991
Soluble in DMSO (13 mg/ml at 25° C), chloroform, DMF (~1.6 mg/ml), and ethanol (<1 mg/ml at 25° C). Insoluble in water.
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McClellan et alMcClellan et al. (PubMed ID 9878991) found that the angiotensin II receptor antagonist selectively inactivated AT1 receptor without affecting other circulatory system receptors involved. -SCBT Publication Review
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