TelbivudineA specific hepatitis B virus (HBV) replication inhibitor

Telbivudine (CAS 3424-98-4)

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Synonym: L-Thymidine; 2'-Deoxy-L-thymidine; 1-(2-deoxy-b-L-erythro-pentofuranosyl)thymine
Application: A specific hepatitis B virus (HBV) replication inhibitor
CAS Number: 3424-98-4
Purity: ≥99%
Molecular Weight: 242.23
Molecular Formula: C10H14N2O5
* Refer to Certificate of Analysis for lot specific data (including water content).
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Telbivudine is a nucleoside analog. A specific inhibitor of hepatitis B virus (HBV) replication. Antiviral.


References

Standring, D.N., et al.: Antiviral. Chem. Chemother., 12, 119 (2001), Hernandez-Santiago, B., et al.: Antimicrob. Agents Chemother., 46, 1728 (2002), Lai, C.-L., et al.: Hepatology, 40, 719 (2004), Han, S.-H.B., et al.: Expert Opin. Invest. Drugs, 14, 511 (2005),

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in water (48 mg/ml at 25° C), DMSO (48 mg/ml at 25° C), and ethanol (2 mg/ml at 25° C).
Storage :
Store at -20° C
Melting Point :
188-190° C
Refractive Index :
n20D 1.58 (Predicted)
Optical Activity :
α20/D -18.5º±3.5º, c = 1 in water; α20/D -17.0º, c = 0.2 in water
IC50 :
Human immunodeficiency virus 1: EC5050 > 0.6 mM
pK Values :
pKa: 9.55 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
UV9048500
PubChem CID :
159269
MDL Number :
MFCD02683612
SMILES :
CC1=CN(C(=O)NC1=O)[C@@H]2C[C@H]([C@@H](O2)CO)O

Download SDS (MSDS)

Certificate of Analysis

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