TCS 21311 CAS: 1260181-14-3
MF: C27H25F3N4O4
MW: 526.51
A potent inhibitor of JAK3.

TCS 21311 (CAS 1260181-14-3)

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Application: TCS 21311 is a potent inhibitor of JAK3
CAS Number: 1260181-14-3
Purity: >98%
Molecular Weight: 526.51
Molecular Formula: C27H25F3N4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
* Refer to Certificate of Analysis for lot specific data (including water content).
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TCS 21311 is a potent JAK3 inhibitor (IC50 = 8 nM). TCS 21311 is selective for JAK3 over JAK1, JAK2 and Tyk 2 (IC50 values are 1017, 2550 and 8055 nM respectively). TCS 21311 also inhibits GSK-3 beta, PKCα, and PKCθ (IC50 values are 3, 13 and 68 nM respectively).

Physical State :
Solid
Solubility :
Soluble to 100 mM in DMSO
Storage :
Desiccate at room temperature
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
PubChem CID :
SMILES :
CC(C)(C(=O)N1CCN(CC1)C2=CC(=C(C=C2)C(F)(F)F)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54)O

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Certificate of Analysis

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