Anti-TCR V β 8.1-3 Antibody (F23.1) is a mouse monoclonal IgG2a κ TCR V β 8.1-3 antibody, cited in 1 publications, provided at 200 µg/ml
raised against BALB.B mouse lymph-node and spleen T cells
recommended for detection of TCR V β 8.1-3 of mouse origin by WB, IP and FCM
available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for TCR V β 8.1-3 Antibody (F23.1) for WB applications. These reagents are now offered in bundles with TCR V β 8.1-3 Antibody (F23.1) (see ordering information below).
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TCR V β 8.1-3 Antibody (F23.1) is a high quality monoclonal TCR V beta 8.1-3 antibody (also designated T cell antigen receptor beta 8.1-3 antibody) suitable for the detection of the TCR V beta 8.1-3 protein of mouse origin. TCR V β 8.1-3 Antibody (F23.1) is available as both the non-conjugated anti-TCR V beta 8.1-3 antibody form, as well as multiple conjugated forms of anti-TCR V beta 8.1-3 antibody, including PE, FITC. The T cell antigen receptor (TCR) recognizes foreign antigens and translates such recognition events into intracellular signals that elicit a change in the cell from a dormant to an activated state. TCR is a heterodimer composed of either α and β or γ and δ chains. The vast majority of circulating T cells (95%) express the α/β heterodimer while roughly 2-5% express the γ/δ heterodimer. Recognizing such a variety of antigens requires diverse specificities in the TCR repertoire. This is obtained by the somatic recombination of variable (V), diversity (D) and joining (J) gene segments in the assembly of each TCR chain. The TCR β and γ chain genes lie in distinct loci, while the genes encoding the TCR α and δ chains comprise a single locus. During T cell development, the β chain is synthesized by first joining a D segment with a J segment, then adding a V segment with the D-J gene, and later a C segment. Genetic mutations involving the T cell receptor β locus have been associated with T cell lymphomas.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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