TCR γ/δ Antibody (3H2928): sc-73122

TCR γ/δ Antibody (3H2928) is a hamster monoclonal IgG antibody that detects TCR γ/δ in mouse samples through immunofluorescence (IF) and flow cytometry (FCM) applications. TCR γ/δ is a crucial component of the immune system, primarily expressed on a subset of T cells that play a significant role in the recognition of non-peptide antigens, which are often derived from microbial sources. Unlike the more common TCR α/β, TCR γ/δ T cells are known for their ability to respond rapidly to infections and stress signals, making them essential for the early immune response. These T cells are predominantly located in epithelial tissues, such as the skin and gut, where they contribute to the first line of defense against pathogens. The unique localization of TCR γ/δ T cells allows them to act quickly in response to tissue damage or infection, highlighting their importance in maintaining tissue homeostasis and immune surveillance. Anti-TCR γ/δ antibody (3H2928) is an invaluable tool for researchers studying the dynamics of T cell responses and the role of these specialized T cells in various immunological contexts.

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TCR γ/δ Antibody (3H2928) References:

1. Tissue-specific segregation of TCRgamma delta+ NKT cells according to phenotype TCR repertoire and activation status: parallels with TCR alphabeta+NKT cells.  |  Lees, RK., et al. 2001. Eur J Immunol. 31: 2901-9. PMID: 11592065
2. Immature thymocytes that fail to express TCRbeta and/or TCRgamma delta proteins die by apoptotic cell death in the CD44(-)CD25(-) (DN4) subset.  |  Falk, I., et al. 2001. Eur J Immunol. 31: 3308-17. PMID: 11745348
3. Disruption of the RanBP17/Hox11L2 region by recombination with the TCRdelta locus in acute lymphoblastic leukemias with t(5;14)(q34;q11).  |  Hansen-Hagge, TE., et al. 2002. Leukemia. 16: 2205-12. PMID: 12399963
4. Chromosomal excision of TCRdelta chain genes is dispensable for alphabeta T cell lineage commitment.  |  Khor, B., et al. 2005. Int Immunol. 17: 225-32. PMID: 15642954
5. Recombination signal sequence-associated restriction on TCRdelta gene rearrangement affects the development of tissue-specific gammadelta T cells.  |  Uche, UN., et al. 2009. J Immunol. 183: 4931-9. PMID: 19801518
6. Gene regulation within the TCR-alpha/delta locus by specific deletion of the TCR-delta cluster.  |  de Villartay, JP. and Cohen, DI. 1990. Res Immunol. 141: 618-23. PMID: 2151349
7. A second TCRδ locus in Galliformes uses antibody-like V domains: insight into the evolution of TCRδ and TCRμ genes in tetrapods.  |  Parra, ZE., et al. 2012. J Immunol. 188: 3912-9. PMID: 22407916
8. Aberrant TCRδ rearrangement underlies the T-cell lymphocytopenia and t(12;14) translocation associated with ATM deficiency.  |  Jiang, W., et al. 2015. Blood. 125: 2665-8. PMID: 25721125
9. A discrete chromatin loop in the mouse Tcra-Tcrd locus shapes the TCRδ and TCRα repertoires.  |  Chen, L., et al. 2015. Nat Immunol. 16: 1085-93. PMID: 26258942
10. Ancient Use of Ig Variable Domains Contributes Significantly to the TCRδ Repertoire.  |  Deiss, TC., et al. 2019. J Immunol. 203: 1265-1275. PMID: 31341077

The preferred TCR δ antibody is TCR δ Antibody (H-41): sc-100289.