TCPOBOP CAS: 76150-91-9
MF: C16H8Cl4N2O2
MW: 402.06
The most potent activator of the phenobarbital-like class of cytochrome P450 (CYP)-inducing agents..

TCPOBOP (CAS 76150-91-9)

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Alternate Names: 1,4-bis(2-(3,5-dichloropyridyloxy))benzene
Application: TCPOBOP is the most potent activator of the phenobarbital-like class of cytochrome P450 (CYP)-inducing agents.
CAS Number: 76150-91-9
Purity: ≥98%
Molecular Weight: 402.06
Molecular Formula: C16H8Cl4N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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TCPOBOP is the most potent known member of the phenobarbital-like class of cytochrome P450 (CYP)-inducing agents. TCPOBOP induces activity of ER1 cytochrome P450 isozymes, NADPH-cytochrome c reductase, microsomal epoxide hydrolase and glutathione S transferase. Potent mitogen; induces liver cell proliferation in mice TCPOBOP acts as a tumor promoter of murine hepatocarcinogenesis; activates orphan nuclear receptors mCAR (mouse Constitutive Androstane Receptor) and hPXR(human Pregnane X Receptor), but has little or no activity on hCAR and mPXR. Additionally, TCPOBOP also suppresses the multidrug resistance gene expression in mouse liver cells.


References

Ledda-Columbano, G.M., et al. 2000. Am. J. Pathol. 156, 91. Moore, L.B., et al. 2000. J. Biol. Chem. 275, 15122. Tzameli, I., et al. 2000. Mol. Cell. Biol. 20, 2951. Forman, B.M., et al. 1998. Nature 395, 612. Honkakoski, P., et al. 1998. Mol. Pharmacol. 53, 597. Russell, A.L., et al. 1994. Int. J. Cancer 58, 550. Smith, G., et al. 1993. Biochem. J. 289, 807. Dargani, T.A., et al. 1990. Carcinogenesis 11, 1153. Poland, A., et al. 1980. Mol. Pharmacol. 18, 571. R: 40; S: 22-36

Usage :
Store as supplied, at room temperature for up to 1 year.Store solutions at -20°C for up to 3 months.
Physical State :
Solid
Solubility :
Soluble in DMSO (5 mg/ml). Insoluble in water.
Storage :
Store at room temperature
Melting Point :
155-157° C
Boiling Point :
444.8° C at 760 mmHg (Predicted)
Density :
~1.5 g/cm3 (Predicted)
Refractive Index :
n20D 1.64 (Predicted)
IC50 :
HEK293 : EC5050 = 50 nM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
UT7145000
PubChem CID :
MDL Number :
MFCD00057368
SMILES :
C1=CC(=CC=C1OC2=C(C=C(C=N2)Cl)Cl)OC3=C(C=C(C=N3)Cl)Cl

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Certificate of Analysis

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TCPOBOP (CAS 76150-91-9)  Product Citations

See how others have used TCPOBOP (CAS 76150-91-9). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 33761883  Goldfarb, CN.|Waxman, DJ.| et al. 2021. BMC Genomics. 22: 212.

Citations 1 to 1 of 1 total
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