TCPOBOP is the most potent known member of the phenobarbital-like class of cytochrome P450 (CYP)-inducing agents. TCPOBOP induces activity of ER1 cytochrome P450 isozymes, NADPH-cytochrome c reductase, microsomal epoxide hydrolase and glutathione S transferase. Potent mitogen; induces liver cell proliferation in mice TCPOBOP acts as a tumor promoter of murine hepatocarcinogenesis; activates orphan nuclear receptors mCAR (mouse Constitutive Androstane Receptor) and hPXR(human Pregnane X Receptor), but has little or no activity on hCAR and mPXR. Additionally, TCPOBOP also suppresses the multidrug resistance gene expression in mouse liver cells.
Ledda-Columbano, G.M., et al. 2000. Am. J. Pathol. 156, 91. Moore, L.B., et al. 2000. J. Biol. Chem. 275, 15122. Tzameli, I., et al. 2000. Mol. Cell. Biol. 20, 2951. Forman, B.M., et al. 1998. Nature 395, 612. Honkakoski, P., et al. 1998. Mol. Pharmacol. 53, 597. Russell, A.L., et al. 1994. Int. J. Cancer 58, 550. Smith, G., et al. 1993. Biochem. J. 289, 807. Dargani, T.A., et al. 1990. Carcinogenesis 11, 1153. Poland, A., et al. 1980. Mol. Pharmacol. 18, 571. R: 40; S: 22-36
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