TCPOBOPThe most potent activator of the phenobarbital-like class of cytochrome P450 (CYP)-inducing agents.

TCPOBOP (CAS 76150-91-9)

TCPOBOP | CAS 76150-91-9 is rated 5.0 out of 5 by 1.
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Synonym: 1,4-bis(2-(3,5-dichloropyridyloxy))benzene
Application: The most potent activator of the phenobarbital-like class of cytochrome P450 (CYP)-inducing agents.
CAS Number: 76150-91-9
Purity: ≥98%
Molecular Weight: 402.06
Molecular Formula: C16H8Cl4N2O2
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

TCPOBOP is the most potent known member of the phenobarbital-like class of cytochrome P450 (CYP)-inducing agents. TCPOBOP induces activity of ER1 cytochrome P450 isozymes, NADPH-cytochrome c reductase, microsomal epoxide hydrolase and glutathione S transferase. Potent mitogen; induces liver cell proliferation in mice TCPOBOP acts as a tumor promoter of murine hepatocarcinogenesis; activates orphan nuclear receptors mCAR (mouse Constitutive Androstane Receptor) and hPXR(human Pregnane X Receptor), but has little or no activity on hCAR and mPXR. Additionally, TCPOBOP also suppresses the multidrug resistance gene expression in mouse liver cells.


References

Ledda-Columbano, G.M., et al. 2000. Am. J. Pathol. 156, 91. Moore, L.B., et al. 2000. J. Biol. Chem. 275, 15122. Tzameli, I., et al. 2000. Mol. Cell. Biol. 20, 2951. Forman, B.M., et al. 1998. Nature 395, 612. Honkakoski, P., et al. 1998. Mol. Pharmacol. 53, 597. Russell, A.L., et al. 1994. Int. J. Cancer 58, 550. Smith, G., et al. 1993. Biochem. J. 289, 807. Dargani, T.A., et al. 1990. Carcinogenesis 11, 1153. Poland, A., et al. 1980. Mol. Pharmacol. 18, 571. R: 40; S: 22-36

Usage :
Store as supplied, at room temperature for up to 1 year.Store solutions at -20°C for up to 3 months.
Physical State :
Solid
Solubility :
Soluble in DMSO (5 mg/ml). Insoluble in water.
Storage :
Store at room temperature
Melting Point :
155-157° C
Boiling Point :
444.8° C at 760 mmHg (Predicted)
Density :
~1.5 g/cm3 (Predicted)
Refractive Index :
n20D 1.64 (Predicted)
IC50 :
HEK293 : EC5050 = 50 nM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
UT7145000
PubChem CID :
5382
MDL Number :
MFCD00057368
SMILES :
C1=CC(=CC=C1OC2=C(C=C(C=N2)Cl)Cl)OC3=C(C=C(C=N3)Cl)Cl

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Oshida K; et al Oshida K; et al. (PubMed ID: 26215100)determined that TCPOBOP inhibited aryl hydrocarbon receptor in mouse liver. -SCBT Publication Review
Date published: 2015-03-20
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