TCP-1 α Antibody (4E215): sc-58862
- TCP-1 α Antibody (4E215) is a rat monoclonal IgG2c provided at 200 µg/ml
- raised against purified recombinant TCP-1 α of mouse origin
- recommended for detection of TCP-1 α of mouse, rat, bovine and canine origin by WB, IP and IF; may cross-react with the p102B' COP subunit of Golgi coatomer; non cross-reactive with human HSP 60
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for TCP-1 α Antibody (4E215). This work is in progress.
TCP-1 α Antibody (4E215) is a rat monoclonal IgG2c antibody that detects TCP-1 in mouse, rat, bovine, and canine samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). TCP-1, or t complex polypeptide 1, is a crucial subunit of the chaperonin containing TCP-1 (CCT) complex, which is essential for the proper folding of cytosolic proteins, particularly actins and tubulins. The CCT complex is composed of eight distinct subunits, each encoded by different genes, and plays a vital role in maintaining cellular function by ensuring proteins achieve their correct three-dimensional structures. TCP-1 α (4E215) monoclonal antibody enables researchers to study TCP-1′s involvement in various cellular processes, including cell division and cytoskeletal organization, which are critical for maintaining cell integrity and functionality. TCP-1′s role extends to developmental processes, as its absence can lead to embryonic lethality in model organisms. TCP-1 α (4E215) antibody serves as an invaluable tool for researchers studying protein folding and related cellular mechanisms, given TCP-1′s significant role in cellular homeostasis and protein interactions.
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TCP-1 α Antibody (4E215) References:
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- The chaperonin genes of jakobid and jakobid-like flagellates: implications for eukaryotic evolution. | Archibald, JM., et al. 2002. Mol Biol Evol. 19: 422-31. PMID: 11919283
- The role of plant CCTalpha in salt- and osmotic-stress tolerance. | Yamada, A., et al. 2002. Plant Cell Physiol. 43: 1043-8. PMID: 12354922
- Expansion of the nucleoplasmic reticulum requires the coordinated activity of lamins and CTP:phosphocholine cytidylyltransferase alpha. | Gehrig, K., et al. 2008. Mol Biol Cell. 19: 237-47. PMID: 17959832
- Calmodulin antagonizes a calcium-activated SCF ubiquitin E3 ligase subunit, FBXL2, to regulate surfactant homeostasis. | Chen, BB., et al. 2011. Mol Cell Biol. 31: 1905-20. PMID: 21343341
- CTP:phosphocholine cytidylyltransferase α (CCTα) and lamins alter nuclear membrane structure without affecting phosphatidylcholine synthesis. | Gehrig, K. and Ridgway, ND. 2011. Biochim Biophys Acta. 1811: 377-85. PMID: 21504799
- Choline phosphate cytidylyltransferase-α is a novel antigen detected by the anti-ERCC1 antibody 8F1 with biomarker value in patients with lung and head and neck squamous cell carcinomas. | Vaezi, AE., et al. 2014. Cancer. 120: 1898-907. PMID: 24692084
- Phospholipid synthesis fueled by lipid droplets drives the structural development of poliovirus replication organelles. | Viktorova, EG., et al. 2018. PLoS Pathog. 14: e1007280. PMID: 30148882
- Interdomain communication in the phosphatidylcholine regulatory enzyme, CCTα, relies on a modular αE helix. | Taneva, SG., et al. 2019. J Biol Chem. 294: 15517-15530. PMID: 31488547
- Resistance to 2-Hydroxy-Flutamide in Prostate Cancer Cells Is Associated with the Downregulation of Phosphatidylcholine Biosynthesis and Epigenetic Modifications. | Mora-Rodríguez, JM., et al. 2023. Int J Mol Sci. 24: PMID: 37958610
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TCP-1 α Antibody (4E215) | sc-58862 | 200 µg/ml | $316.00 |