TCP-1 α Antibody (22b): sc-53451
- TCP-1 α Antibody (22b) is a rat monoclonal IgG2a provided at 200 µg/ml
- raised against the C-terminal half of TCP of murine origin
- recommended for detection of TCP-1 α of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for TCP-1 α Antibody (22b). This work is in progress.
TCP-1 α Antibody (22b) is a rat monoclonal IgG2a antibody that detects TCP-1 α in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). TCP-1 α is a crucial subunit of the chaperonin containing TCP-1 (CCT) complex, which is essential for the proper folding of cytosolic proteins, particularly actins and tubulins. The CCT complex is composed of eight distinct subunits, each encoded by different genes, and plays a vital role in maintaining cellular homeostasis by ensuring that proteins achieve their functional conformations. TCP-1 α′s importance extends beyond CCT complex involvement to various cellular processes, including cell division and differentiation. Abnormalities in TCP-1 α function can lead to misfolded proteins, which are implicated in several diseases, highlighting TCP-1 α′s significance in both basic biology and potential therapeutic applications. Anti-TCP-1 α antibody (22b) serves as an invaluable tool for researchers studying protein folding and related cellular mechanisms.
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TCP-1 α Antibody (22b) References:
- Cytosolic chaperonin-containing t-complex polypeptide 1 changes the content of a particular subunit species concomitant with substrate binding and folding activities during the cell cycle. | Yokota, S., et al. 2001. Eur J Biochem. 268: 4664-73. PMID: 11532003
- A subclass of myosin XI is associated with mitochondria, plastids, and the molecular chaperone subunit TCP-1alpha in maize. | Wang, Z. and Pesacreta, TC. 2004. Cell Motil Cytoskeleton. 57: 218-32. PMID: 14752806
- Characterization of a tightly controlled promoter of the halophilic archaeon Haloferax volcanii and its use in the analysis of the essential cct1 gene. | Large, A., et al. 2007. Mol Microbiol. 66: 1092-106. PMID: 17973910
- Chaperonin containing T-complex polypeptide (CCT) subunit expression in oral mucosal wounds and fibroblasts. | Satish, L., et al. 2011. Cell Stress Chaperones. 16: 675-80. PMID: 21710295
- Comparative expression analysis of pfdn6a and tcp1α during Xenopus development. | Marracci, S., et al. 2015. Int J Dev Biol. 59: 235-40. PMID: 26009237
- HtrA3 is a cellular partner of cytoskeleton proteins and TCP1α chaperonin. | Wenta, T., et al. 2018. J Proteomics. 177: 88-111. PMID: 29477555
- Chaperonin-containing T‑complex protein 1 subunit 8 promotes cell migration and invasion in human esophageal squamous cell carcinoma by regulating α-actin and β-tubulin expression. | Yang, X., et al. 2018. Int J Oncol. 52: 2021-2030. PMID: 29620162
- Chaperones in sporadic inclusion body myositis-Validation of proteomic data. | Güttsches, AK., et al. 2020. Muscle Nerve. 61: 116-121. PMID: 31644823
- Disruption of actin dynamics induces autophagy of the eukaryotic chaperonin TRiC/CCT. | Date, Y., et al. 2022. Cell Death Discov. 8: 37. PMID: 35079001
- Functional role of a consensus peptide which is common to alpha-, beta-, and gamma-tubulin, to actin and centractin, to phytochrome A, and to the TCP1 alpha chaperonin protein. | Burns, RG. and Surridge, CD. 1994. FEBS Lett. 347: 105-111. PMID: 8033985
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TCP-1 α Antibody (22b) | sc-53451 | 200 µg/ml | $316.00 |