TC-H 106A class I HDAC (histone deacetylase) inhibitor

TC-H 106 (CAS 937039-45-7)

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Synonym: Histone Deacetylase Inhibitor VII; Pimelic Diphenylamide 106
Application: A class I HDAC (histone deacetylase) inhibitor
CAS Number: 937039-45-7
Purity: >99%
Molecular Weight: 339.43
Molecular Formula: C20H25N3O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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TC-H 106 is a Class I HDAC (histone deacetylase) inhibitor of HDAC1, HDAC3, HDAC2 and HDAC8 with IC50 of 150, 370, 760 and 5000 nM respectively. TC-H 106 exhibits slow, tight-binding inhibitory activity. TC-H 106 displays no activity against Class II HDACs.

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), ethanol (50 mM), DMF (~20 mg/ml), and 1:1solution of DMSO:PBS(pH7.2) (~0.5 mg/ml).
Storage :
Store at -20° C
Melting Point :
258.62° C (Predicted)
Boiling Point :
~627.3° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.64 (Predicted)
IC50 :
HDAC1: IC50 = 150 nM; HDAC2: IC50 = 760 nM; HDAC3: IC50 = 370 nM; HDAC8: IC50 = 5 µM; HDAC4: IC50 >180 µM; HDAC5: IC50 >180 µM; HDAC7: IC50 >180 µM
Ki Data :
HDAC3: Ki= 14 nM; HDAC1 : Ki= 148
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
16070100
MDL Number :
MFCD17010287
SMILES :
CC1=CC=C(C=C1)NC(=O)CCCCCC(=O)NC2=CC=CC=C2N

Download SDS (MSDS)

Certificate of Analysis

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