Anti-TBL1 Antibody (H-3) is a mouse monoclonal IgG1 κ TBL1 antibody, cited in 3 publications, provided at 200 µg/ml
raised against amino acids 211-577 of TBL1X of human origin
TBL1 Antibody (H-3) is recommended for detection of TBL1X of mouse, rat and human origin and TBL1Y of human origin by WB, IP, IF and ELISA
Anti-TBL1 Antibody (H-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
TransCruz reagent for ChIP application (sc-137006 X, 200 µg/0.1 ml)
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of TBL1 (H-3): sc-137006.
m-IgGκ BP-HRP is the preferred secondary detection reagent for TBL1 Antibody (H-3) for WB applications. This reagent is now offered in a bundle with TBL1 Antibody (H-3) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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TBL1 Antibody (H-3) is a high quality monoclonal TBL1 antibody (also designated TBL1 antibody) suitable for the detection of the TBL1 protein of mouse, rat and human origin. TBL1 Antibody (H-3) is available as both the non-conjugated anti-TBL1 antibody form, as well as multiple conjugated forms of anti-TBL1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. TBL1, for transducin β-like 1, is a ubiquitously expressed protein that contains six distinct β-transducin repeats, known also as WD40 repeats, within the C-terminal domain. Transducin β-like 1 Y-linked protein (TBL1Y), also designated F-box-like/WD-repeat protein, and transducin β-like 1 X protein (TBL1X), also known as SMAP55, are nuclear F-box-like proteins. They are important in the ubiquitin/19S proteasome complex recruitment to nuclear receptor-regulated transcription units. TBL1X is a part of the N-CoR repressor complex together with N-CoR1, N-CoR2, HDAC3, TBL1R, CORO2A and GPS2. It is also a component of the E3 ubiquitin ligase complex. TBL1X, which can interact with Histones H2B, H3a and H4, is similar to TBL1Y but is localized on chromosome Xp22.3. Defects in TBL1X may cause an X-linked human disorder called ocular albinism with late-onset sensorineural deafness (OASD). TBL1Y is an X-degenerate gene that is homologous to TBL1X. TBL1Y, a single-copy gene, localizes to human chromosome Yp11.2 in the male-specific region of chromosome Y (MSY). This region of the Y chromosome does not engage in X-Y crossover events. TBL1Y is primarily expressed in fetal brain and prostate. TBL1X and TBL1Y are crucial in nuclear receptor mediated transcription activation.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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