TBL1 Antibody (H-11) is a mouse monoclonal IgG1 (kappa light chain) provided at 200 µg/ml
raised against amino acids 211-577 of TBL1X of human origin
recommended for detection of TBL1X of mouse, rat and human origin and TBL1Y of human origin by WB, IP, IF, IHC(P) and ELISA
TransCruz reagent for ChIP application (sc-137083 X, 200 µg/0.1 ml)
m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for TBL1 Antibody (H-11) for WB and IHC(P) applications. These reagents are now offered in bundles with TBL1 Antibody (H-11) (see ordering information below).
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
TBL1, for transducin β-like 1, is a ubiquitously expressed protein that contains six distinct β-transducin repeats, known also as WD40 repeats, within the C-terminal domain. Transducin β-like 1 Y-linked protein (TBL1Y), also designated F-box-like/WD-repeat protein, and transducin β-like 1 X protein (TBL1X), also known as SMAP55, are nuclear F-box-like proteins. They are important in the ubiquitin/19S proteasome complex recruitment to nuclear receptor-regulated transcription units. TBL1X is a part of the N-CoR repressor complex together with N-CoR1, N-CoR2, HDAC3, TBL1R, CORO2A and GPS2. It is also a component of the E3 ubiquitin ligase complex. TBL1X, which can interact with Histones H2B, H3a and H4, is similar to TBL1Y but is localized on chromosome Xp22.3. Defects in TBL1X may cause an X-linked human disorder called ocular albinism with late-onset sensorineural deafness (OASD). TBL1Y is an X-degenerate gene that is homologous to TBL1X. TBL1Y, a single-copy gene, localizes to human chromosome Yp11.2 in the male-specific region of chromosome Y (MSY). This region of the Y chromosome does not engage in X-Y crossover events. TBL1Y is primarily expressed in fetal brain and prostate. TBL1X and TBL1Y are crucial in nuclear receptor mediated transcription activation.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.