TazaroteneA prodrug for tazarotenic acid with selective affinity for RARβ and RARγ

Tazarotene (CAS 118292-40-3)

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Application: A prodrug for tazarotenic acid with selective affinity for RARβ and RARγ
CAS Number: 118292-40-3
Purity: ≥99%
Molecular Weight: 351.46
Molecular Formula: C21H21NO2S
* Refer to Certificate of Analysis for lot specific data (including water content).
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Tazarotene is an acetylenic retinoid prodrug of tazarotenic acid (sc-212992) with selective affinity for retinoic acid receptors RARβ and RARγ. Tazarotene also upregulates tazarotene-induced genes (TIGs), including the cell adhesion molecule TIG1 and the tumor-suppressor TIG3.


References

1. Tang-Liu, D D., et al., 1999. Clinical pharmacokinetics and drug metabolism of tazarotene: a novel topical treatment for acne and psoriasis. Clinical pharmacokinetics. 37(4): 273-87. PMID: 10554045
2. Roeder, A., et al., . Tazarotene: therapeutic strategies in the treatment of psoriasis, acne and photoaging. Skin pharmacology and physiology. 17(3): 111-8. PMID: 15087589

Physical State :
Solid
Solubility :
Soluble in water (partly), chloroform, DMSO (>15 mg/ml), methanol, and ethanol (50 mM).
Storage :
Store at 4° C
Melting Point :
95-98° C
Boiling Point :
~499.8° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.63 (Predicted)
IC50 :
RAR beta: EC5050 = 0.8 nM (human); RAR gamma: EC5050 = 40 nM (human); RAR alpha: EC5050 = 63 nM (human)
pK Values :
pKb: 0.04 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
US5675100
PubChem CID :
5381
MDL Number :
MFCD00867628
Beilstein Registry :
8159145
SMILES :
CCOC(=O)C1=CN=C(C=C1)C#CC2=CC3=C(C=C2)SCCC3(C)C

Download SDS (MSDS)

Certificate of Analysis

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