TaxolAn antineoplastic and apoptosis inducing agent

Taxol (CAS 33069-62-4)

Taxol | CAS 33069-62-4 is rated 5.0 out of 5 by 1.
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Synonym: Paclitaxel
Application: An antineoplastic and apoptosis inducing agent
CAS Number: 33069-62-4
Purity: ≥99%
Molecular Weight: 853.90
Molecular Formula: C47H51NO14
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Taxol, an antineoplastic and antimicrotubule agent, posses mechanisms of cytotoxic action and has a broad antineoplastic spectrum compared to the vinca alkaloids. Studies have shown that Taxol is an inhibitor of neurite outgrowth and initiation by destroying normal control of microtuble assemly in growing neurites and removing tubulin from the cytoplasm. At lower concentrations Taxol displays the capacity to slightly enhance the mechanisms of microtubule assembly in neurons, and in turn changes the morphogenetic properties of growing neurites. The mechanism for microtuble formation occurs by binding of Taxol to the N-terminal region of β-tubulin. These new microtubules are highly stable and resist depolymerization therefore preventing normal cell division and arresting cell cycle at the G2/M phase. It has been reported that Taxol also causes apoptotic cell death, internucleosomal DNA fragmentation, and inhibition of protein isoprenylation. Taxol is a potential activator of PKA and Raf-1.


References

1. Letourneau, P.C., et al. 1984. J. Cell Biol. 98: 1355-1362. PMID: 6143759
2. McGuire, W.P., et al. 1989. Ann. Intern. Med. 111: 273-279. PMID: 2569287
3. Mogensen, M.M. and Tucker, J.B. 1990. J. Cell. Sci. 97: 101-107. PMID: 1979558
4. Rowinsky, E.K., et al. 1990. J. Natl. Cancer Inst. 82: 1247-1259. PMID: 1973737
5. Danesi, R., et al. 1995. Mol. Pharmacol. 47: 1106-1111. PMID: 7603448

Usage :
Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 6 months.
Physical State :
Solid
Derived From :
Taxus brevifolia
Solubility :
Soluble in ethanol (~1.5 mg/ml), DMSO (5 mg/ml), acetonitrile, methanol (50 mg/ml), chloroform, 1:10 DMSO:PBS(pH 7.2) (~0.1 mg/ml), and DMF (~5 mg/ml). Insoluble in water.
Storage :
Store at -20° C
Melting Point :
213° C (dec.)
Boiling Point :
957.12° C at 760 mmHg
Density :
~1.40 g/cm3 (Predicted)
Refractive Index :
n20D 1.64
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
DA8340700
PubChem CID :
36314
Merck Index :
14: 6982
MDL Number :
MFCD00869953
Beilstein Registry :
1420457
SMILES :
CC1=C2[C@H](C(=O)[C@@]3([C@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C

Download SDS (MSDS)

Certificate of Analysis

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Taxol  Product Citations

See how others have used Taxol. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 24 total

PMID: # 30601011  Karthikeyan, S.|Bharanidharan, G.|Ragavan, S.|Kandasamy, S.|Chinnathambi, S.|Udayakumar, K.|Mangaiyarkarasi, R.|Suganya, R.|Aruna, P.|Ganesan, S.| et al. 2019. Mol. Pharm. 16: 669-681.

PMID: # 31291454  Yuan, F.|Jin, X.|Li, D.|Song, Y.|Zhang, N.|Yang, X.|Wang, L.|Zhu, WG.|Tian, C.|Zhao, Y.| et al. 2019. Nucleic Acids Res.

PMID: # 31272829  Fang, MY.|Markmiller, S.|Vu, AQ.|Javaherian, A.|Dowdle, WE.|Jolivet, P.|Bushway, PJ.|Castello, NA.|Baral, A.|Chan, MY.|Linsley, JW.|Linsley, D.|Mercola, M.|Finkbeiner, S.|Lecuyer, E.|Lewcock, JW.|Yeo, GW.| et al. 2019. Neuron.

PMID: # 30578765  Delgado, M.|Urbaniak, A.|Chambers, TC.| et al. 2019. Biochem. Pharmacol. 162: 213-223.

PMID: # 30320402  Zhao, Y. et al. 2019. Oncol. Rep. 41: 501-511.

PMID: # 29630545  Nowak, E. et al. 2018. Clin. Hemorheol. Microcirc. 69: 327-336.

PMID: # 28259950  Shen, F.|Long, D.|Yu, T.|Chen, X.|Liao, Y.|Wu, Y.|Lin, X.| et al. 2017. Oncol. Rep. 37: 2481-2489.

PMID: # 29285257  Choi, B. et al. 2017. Oncotarget. 8: 105372-105382.

PMID: # 28589243  Long, D. et al. 2017. Cell Biol. Toxicol. 34: 7-21.

PMID: # 28159572  Heuer, TS. et al. 2017. EBioMedicine. 16: 51-62.

Citations 1 to 10 of 24 total

how do you make a stock of 10mM of paclitaxel?

Asked by: swetha
Thank you for your question. This chemical, Taxol (CAS 33069-62-4) , is soluble in ethanol (~1.5 mg/ml), DMSO (5 mg/ml), acetonitrile, methanol (50 mg/ml), chloroform, 1:10 DMSO:PBS(pH 7.2) (~0.1 mg/ml), and DMF (~5 mg/ml). Insoluble in water. This is the only information we can provide.
Answered by: Technical Support
Date published: 2017-02-03
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Rated 5 out of 5 by from Danesi Danesi, R. et al. (PubMed 7603448) examined the effects of Taxol (Paclitaxel), an antineoplastic and microtubule affecting agent, in the human prostate cancer cell line PC-3. Treatment of cells with Taxol resulted in a dose-dependent inhibition of cell viability. -SCBT Publication Review
Date published: 2015-02-23
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