TAPSCAS: 29915-38-6
MF: C7H17NO6S
MW: 243.2
A zwitterionic buffer that has a useful pH range of 7.7 - 9.1.

TAPS (CAS 29915-38-6)

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Synonym: N-[Tris(hydroxymethyl)methyl]-3-aminopropanesulfonic acid
Application: A zwitterionic buffer that has a useful pH range of 7.7 - 9.1
CAS Number: 29915-38-6
Purity: ≥99%
Molecular Weight: 243.2
Molecular Formula: C7H17NO6S
* Refer to Certificate of Analysis for lot specific data (including water content).
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TAPS is a zwitterionic buffer used in biochemistry and molecular biology. It has a useful pH range of 7.7 - 9.1. TAPS has been utilized in capillary electrophoresis of DNA and DNA-dye complexes. Dyes can be separated by planar chromatography with electroosmotic flow containing 1 mM TAPS in the mobile phase. The stability constants of metal ions with TAPS have been investigated through the use of capillary electrophoresis. TAPS has also been shown to inhibit the activity of connexin channels. The activity of various carbonic anhydrases has been studied using TAPS physiological buffer, pKa = 8.4 at 20° C.


References

1. Blanchard, J.S. 1984. Meth. Enzymol. 104: 404-414. PMID: 6717292
2. Tu, C.K., et al. 1989. Biochemistry. 28: 7913-7918. PMID: 2514797
3. Ren, X. and Lindskog, S. 1992. Biochim. Biophys. Acta. 1120: 81-86. PMID: 1554744
4. Engstrand, C., 1992. Biochim. Biophys. Acta. 1122: 321-326. PMID: 1354487
5. Zeng, Z., et al. 1997. Anal. Biochem. 252: 110-114. PMID: 9324948
6. Bevans, C.G. and Harris, A.L. 1999. J. Biol. Chem. 274: 3711-3719. PMID: 9920923
7. Nurok, D., et al. 2000. J Chromatogr A. 903: 211-217. PMID: 11153944
8. Wei, W. and Yeung, E.S. 2000. J. Chromatogr. B Biomed. Sci. Appl. 745: 221-230. PMID: 10997717
9. Li, L. and McGown, L.B. 2001. Fresenius J Anal Chem. 369: 267-272. PMID: 11293703
10. Liang, D., et al. 2001. J Chromatogr A. 931: 163-173. PMID: 11695518
11. Muzikár, M., et al. 2002. Electrophoresis. 23: 1796-1802. PMID: 12116122

Physical State :
Solid
Solubility :
Soluble in water (500 mg/ml).
Storage :
Store at room temperature
Melting Point :
230-235° C (dec.)
Refractive Index :
n20D 1.56 (Predicted)
IC50 :
HIV-1(RF): IC50 = >200 µM (CEM)
pK Values :
pKa: 8.4(25°C)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
121591
Merck Index :
14: 9058
MDL Number :
MFCD00007538
EC Number :
249-954-1
Beilstein Registry :
2452420
SMILES :
C(CNC(CO)(CO)CO)CS(=O)(=O)O

Download SDS (MSDS)

Certificate of Analysis

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