Tanshinone IA biochemical that displays cytotoxicity against IFN-g production in KLH-primed lymph node cells

Tanshinone I (CAS 568-73-0)

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Synonym: Tanshinone A; Tanshinquinone I; 1,6-Dimethylphenanthro[1,2-b]furan-10,11-dione
Application: A biochemical that displays cytotoxicity against IFN-g production in KLH-primed lymph node cells
CAS Number: 568-73-0
Molecular Weight: 276.29
Molecular Formula: C18H12O3
* Refer to Certificate of Analysis for lot specific data (including water content).
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Tanshinone I is a pigment isolated from the herbal medicine Salvia miltiorrhiza Bunge. Tanshinone I displays cytotoxicity against human macrophages and IFN-g production in KLH-primed lymph node cells.


References

Li ZT, Yang BJ, Ma GE. Acta Pharm Sinica. 26:209-213 (1991). Ryu SY, Lee CO, Choi SU, Planta Medica. 63:339-342 (1997). Kang BY, Chung SW, Kim SH et. al. Immunopharm. 49:355-361 (2000).

Appearance :
Powder or crystalline
Physical State :
Solid
Solubility :
Soluble in DMSO (23 mg/ml at 25° C), methanol (5 mg/ml), chloroform, water (<1 mg/ml at 25° C), and ethanol (<1 mg/ml at 25° C).
Storage :
Store at 4° C
Melting Point :
229-234° C
Boiling Point :
474-522° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.68 (Predicted)
IC50 :
SARS coronavirus 3C-like proteinase: IC50 = 700 nM (SARS coronavirus); MIA PaCa-2: IC50 = 10.5 µM (human); AGS: IC50 >50 µM (human)
Ki Data :
SARS coronavirus 3C-like proteinase: Ki= 13.7 µM (SARS coronavirus)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
114917
MDL Number :
MFCD00210563
SMILES :
CC1=CC=CC2=C1C=CC3=C2C(=O)C(=O)C4=C3OC=C4C

Download SDS (MSDS)

Certificate of Analysis

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