TamoxifenA selective estrogen response modifier (SERM), protein kinase C inhibitor and anti-angiogenetic factor

Tamoxifen (CAS 10540-29-1)

Tamoxifen | CAS 10540-29-1 is rated 5.0 out of 5 by 2.
  • y_2019, m_9, d_18, h_8
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.13
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_2
  • loc_en_US, sid_208414, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 89ms
  • REVIEWS, PRODUCT
Synonym: (Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine; Mammaton; Novaldex; Tamoxifen; Z-Tamoxifen; trans-Tamoxife
Application: A selective estrogen response modifier (SERM), protein kinase C inhibitor and anti-angiogenetic factor
CAS Number: 10540-29-1
Purity: ≥99%
Molecular Weight: 371.52
Molecular Formula: C26H29NO
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Tamoxifen is a selective estrogen response modifier (SERM), PKC (protein kinase C) inhibitor and anti-angiogenetic factor. Tamoxifen is a prodrug that is metabolized to active metabolites 4-hydroxytamoxifen (4-OHT) and endoxifen by cytochrome P450 isoforms CYP2D6 and CYP3A4. In breast cancer, the gene repressor activity of tamoxifen against ERBB2 is dependent upon PAX2. Blocks estradiol-stimulated VEGF production in breast tumor cells. Tamoxifen induces apoptosis in human malignant glioma cell lines. Tamoxifen is an activator of ER α and ER β.


References

1. Jordan, V.C., et al. 1980. Cancer Treat Rep. 64: 745-759. PMID: 6775807
2. O'Brian, C.A., et al. 1985. Cancer Res. 45: 2462-2465. PMID: 3157445
3. Issandou, M., et al. 1990. Cancer Res. 50: 5845-5850. PMID: 2393853
4. Edwards, K.J., et al. 1992. J. Med. Chem. 35: 2753-2761. PMID: 1322985

Appearance :
Crystalline
Physical State :
Solid
Solubility :
Soluble in Dichloromethane
Storage :
Store at -20° C
Melting Point :
97-98° C (lit.)
Boiling Point :
~482.3° C at 760 mmHg (Predicted)
Density :
~1.0 g/cm3 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
2733526
SMILES :
CC/C(=C(\C1=CC=CC=C1)/C2=CC=C(C=C2)OCCN(C)C)/C3=CC=CC=C3

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

Tamoxifen  Product Citations

See how others have used Tamoxifen. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 30677512  Li, S.|Zhu, Z.|Xue, M.|Yi, X.|Liang, J.|Niu, C.|Chen, G.|Shen, Y.|Zhang, H.|Zheng, J.|Zhao, C.|Liang, Y.|Cong, W.|Wang, Y.|Jin, L.| et al. 2019. Biochim Biophys Acta Mol Basis Dis.

PMID: # 25680947  Chae, YJ. et al. 2015. European journal of pharmacology. 752: 1-7.

PMID: # 24667756  Negreira, N. et al. 2014. The Science of the total environment. 482-483: 389-98.

Citations 1 to 3 of 3 total

sc-208414 tamoxin is in stock?

Asked by: Atsushi
Thank you for your question. Please contact our Customer Care Department for current product availability.
Answered by: Technical Support
Date published: 2019-01-26

How long before it expires?

Asked by: ttttterg3454
All of our products are warrantied for one year from the date purchased. If a CoA with an expiration date is needed, please inquire with Technical Service and one will be provided to you. Please note that all CoAs are lot-specific.
Answered by: Technical Support
Date published: 2018-12-10

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. The compound, sc-208414, is provided as a white crystalline powder. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing scbt@scbt.com, or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2017-11-15
  • y_2019, m_9, d_18, h_8CST
  • bvseo_bulk, prod_bvqa, vn_bulk_2.0.13
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_3
  • loc_en_US, sid_208414, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 169ms
  • QUESTIONS, PRODUCT
Rated 5 out of 5 by from good the rating looks good. I'm planning to get one for my research.
Date published: 2018-04-25
Rated 5 out of 5 by from Bentin Toaldo Bentin Toaldo, C. et al. (PubMed 26272591) found that resistance of Tamoxifen, a selective estrogen response modifier (SERM), protein kinase C inhibitor and anti-angiogenetic factor, in ER -positive breast cancer cells is mediated by the anchoring protein AKAP13. -SCBT Publication Review
Date published: 2015-07-15
  • y_2019, m_9, d_18, h_8
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.13
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_2
  • loc_en_US, sid_208414, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 118ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.