Talnetant (CAS 174636-32-9)
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Talnetant is an investigational compound that has been the focus of numerous studies due to its role as a selective antagonist at the NK3 receptor, a type of neurokinin receptor. This compound has provided researchers with a tool to delve into the function of tachykinin peptides, which are involved in a wide range of CNS activities. In behavioral studies, talnetant helps to elucidate the neurochemical pathways that underpin stress responses, potentially influencing the design of new studies into stress-related disorders. Additionally, its interaction with the NK3 receptor has been useful in neurophysiological research to understand the modulation of neurotransmitter release in the brain. The compound has also been used in endocrinological studies to explore the impact of NK3 receptor pathways on the release of hormones, such as those involved in the regulation of the hypothalamic-pituitary-gonadal axis.
Talnetant (CAS 174636-32-9) References
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- Effect of neurokinins on canine prostate cell physiology. | Walden, PD., et al. 2005. Prostate. 63: 358-68. PMID: 15611996
- Talnetant GlaxoSmithKline. | Evangelista, S. 2005. Curr Opin Investig Drugs. 6: 717-21. PMID: 16044668
- Defensive and pathological functions of the gastrointestinal NK3 receptor. | Sanger, GJ., et al. 2006. Vascul Pharmacol. 45: 215-20. PMID: 16901762
- Neurokinin-3 receptor-specific antagonists talnetant and osanetant show distinct mode of action in cellular Ca2+ mobilization but display similar binding kinetics and identical mechanism of binding in ligand cross-competition. | Tian, G., et al. 2007. Mol Pharmacol. 71: 902-11. PMID: 17172464
- Modulation of peristalsis by NK3 receptor antagonism in guinea-pig isolated ileum is revealed as intraluminal pressure is raised. | Sanger, GJ., et al. 2007. Auton Autacoid Pharmacol. 27: 105-11. PMID: 17391280
- In vitro and in vivo characterization of the non-peptide NK3 receptor antagonist SB-223412 (talnetant): potential therapeutic utility in the treatment of schizophrenia. | Dawson, LA., et al. 2008. Neuropsychopharmacology. 33: 1642-52. PMID: 17728699
- Pharmacological analysis of components of the change in transmural potential difference evoked by distension of rat proximal small intestine in vivo. | Larsson, MH., et al. 2008. Am J Physiol Gastrointest Liver Physiol. 294: G165-73. PMID: 17975133
- Augmentation of antipsychotic-induced neurochemical changes by the NK3 receptor antagonist talnetant (SB-223412). | de la Flor, R. and Dawson, LA. 2009. Neuropharmacology. 56: 342-9. PMID: 18822303
- The tachykinin NK3 receptor agonist senktide induces locomotor activity in male Mongolian gerbils. | Nordquist, RE., et al. 2008. Eur J Pharmacol. 600: 87-92. PMID: 18930726
- Pharmacological characterization of senktide-induced tail whips. | Nordquist, RE., et al. 2010. Neuropharmacology. 58: 259-67. PMID: 19540857
- Identification of a critical residue in the transmembrane domain 2 of tachykinin neurokinin 3 receptor affecting the dissociation kinetics and antagonism mode of osanetant (SR 142801) and piperidine-based structures. | Malherbe, P., et al. 2009. J Med Chem. 52: 7103-12. PMID: 19817444
- Virtual screening to identify novel antagonists for the G protein-coupled NK3 receptor. | Geldenhuys, WJ., et al. 2010. J Med Chem. 53: 8080-8. PMID: 21047106
- Mapping the binding pocket of a novel, high-affinity, slow dissociating tachykinin NK3 receptor antagonist: biochemical and electrophysiological characterization. | Malherbe, P., et al. 2014. Neuropharmacology. 86: 259-72. PMID: 25107588
- Development of novel NK3 receptor antagonists with reduced environmental impact. | Yamamoto, K., et al. 2016. Bioorg Med Chem. 24: 3494-500. PMID: 27298001
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Talnetant, 1 g | sc-475043 | 1 g | $393.00 |