Tadalafil is a potent and selective inhibitor of PDE5A (Phosphodiesterase-5, PDE5). This compound prevents the breakdown of phosphodiesterases, many of which are used as secondary messengers. By preventing the breakdown of these messenger molecules, tadalafil can prolong signal transduction and amplify its effect.
Soluble in DMSO (78 mg/ml at 25° C), methanol, water (< 1 mg/ml at 25° C), dichloromethane, and ethanol (< 1 mg/ml at 25° C).
Store at -20° C
~679.1° C at 760 mmHg (Predicted)
~1.5 g/cm3 (Predicted)
n20D 1.76 (Predicted)
α20/D +56.3°, c = 0.5 in chloroform; α20/D +71°, c = 1 in chloroform
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Rated 5 out of
use it as PDE5A inhibitor and it worked in U87MGuse it as PDE5A inhibitor and it worked in U87MG glioma cell.
Date published: 2017-12-16
Rated 5 out of
EIEI-Sayed, MI. et al. (PubMed 25861307) used Tadalafil, a PDE5 inhibitor, to study its possible endothelial cyto-protective and thrombo-resistance effects in male rabbit models. Tadalafil showed a lower increase in PGF1 (p < 0.001), lower decrease in TXB2 (p < 0.001), and higher increase in calcium levels (p < 0.01, p < 0.05), lower increase in PT and TT levels (p < 0.001) when compared to other PDE5 inhibitors. -SCBT Publication Review
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