TadalafilA phosphodiesterase 5 inhibitor

Tadalafil (CAS 171596-29-5)

Tadalafil | CAS 171596-29-5 is rated 5.0 out of 5 by 2.
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Synonym: (6R,12aR)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methylpyrazino[1,2:1,6]pyrido[3,4-b]indole-1,4-dione; Cialis; GF 196960; IC 351; ICOS 351; Tildenafil; UK 336017
Application: A phosphodiesterase 5 inhibitor
CAS Number: 171596-29-5
Purity: ≥98%
Molecular Weight: 389.40
Molecular Formula: C22H19N3O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Tadalafil is a potent and selective inhibitor of PDE5A (Phosphodiesterase-5, PDE5). This compound prevents the breakdown of phosphodiesterases, many of which are used as secondary messengers. By preventing the breakdown of these messenger molecules, tadalafil can prolong signal transduction and amplify its effect.

Appearance :
Crystalline
Physical State :
Solid
Solubility :
Soluble in DMSO (78 mg/ml at 25° C), methanol, water (< 1 mg/ml at 25° C), dichloromethane, and ethanol (< 1 mg/ml at 25° C).
Storage :
Store at -20° C
Melting Point :
276-279° C
Boiling Point :
~679.1° C at 760 mmHg (Predicted)
Density :
~1.5 g/cm3 (Predicted)
Refractive Index :
n20D 1.76 (Predicted)
Optical Activity :
α20/D +56.3°, c = 0.5 in chloroform; α20/D +71°, c = 1 in chloroform
IC50 :
PDE5A: IC50 = 1.2 nM (human); PDE-5: IC50 = 1.8 nM; PDE11A: IC50 = 33 nM (human); Phosphodiesterase 6: IC50 = 0.98 µM (human); Phosphodiesterase 6A: IC50 = 3 µM (bovine)
Ki Data :
Phosphodiesterase 5A: Ki= 5 nM (rat)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
UQ4431050
PubChem CID :
110635
MDL Number :
MFCD07771966
SMILES :
CN1CC(=O)N2[C@H](CC3=C(NC4=C3C=CC=C4)[C@H]2C2=CC=C3OCOC3=C2)C1=O

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Certificate of Analysis

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Tadalafil  Product Citations

See how others have used Tadalafil. Click on the entry to view the PubMed entry .

Citations 1 to 7 of 7 total

PMID: # 28607126  Lambert, JA. et al. 2017. Hypertension. 70: 390-400.

PMID: # 25578602  Petersen, TS. et al. 2015. Mol. Cell. Endocrinol. 403: 10-20.

PMID: # 25843350  Kim, T. et al. 2015. Metab. Eng. 29: 169-79.

PMID: # 25531864  Lee, S. et al. 2015. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 978-979: 1-10.

PMID: # 23371534  Lee, S. et al. 2013. Anal Bioanal Chem. 405: 3185-94.

PMID: # 22633604  Lanzarotta, A. et al. J Pharm Biomed Anal. 67-68: 22-7.

PMID: # 28163539  Sen, S.|Thomas, A.|Das, S.|Dey, JK.|Peedicayil, A.|Thomas, V.|Peedicayil, J.| et al. J Pharmacol Pharmacother. 7: 177-181.

Citations 1 to 7 of 7 total
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Rated 5 out of 5 by from use it as PDE5A inhibitor and it worked in U87MG use it as PDE5A inhibitor and it worked in U87MG glioma cell.
Date published: 2017-12-16
Rated 5 out of 5 by from EI EI-Sayed, MI. et al. (PubMed 25861307) used Tadalafil, a PDE5 inhibitor, to study its possible endothelial cyto-protective and thrombo-resistance effects in male rabbit models. Tadalafil showed a lower increase in PGF1 (p < 0.001), lower decrease in TXB2 (p < 0.001), and higher increase in calcium levels (p < 0.01, p < 0.05), lower increase in PT and TT levels (p < 0.001) when compared to other PDE5 inhibitors. -SCBT Publication Review
Date published: 2015-06-03
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