T0070907 is a cell-permeable chloro-nitro-benzamido compound that acts as a potent, specific, irreversible, and high-affinity antagonist of PPARγ with a Ki of 1 nM. Displays >800-fold greater selectivity for PPARg over PPARa and PPARd (Ki = 0.85 μM and 1.8 μM, respectively). Blocks hormone- and agonist-induced adipogenesis in 3T3-L1 cells. It suppresses interactions between PPARg and coactivator-derived peptides, while promotes the recruitment of corepressor-derived peptides. Shown to modulate the interaction of PPARg2 with the cofactor proteins through covalent binding to Cys313 in its ligand-binding domain.
Lee, G., et al. 2002. J. Biol. Chem. 277, 19649.
Soluble in DMSO (5 mg/ml), and ethanol (<1 mg/ml at 25° C). Insoluble in water.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Zuckermann et alZuckermann et al. (PubMed ID 26333042) used T0070907 to inhibit PPAR and prevented downstream -catenin degradation while increasing histone 2/3 acetylation in human hepatocarcinoma cell line (Huh7). -SCBT Publication Review
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